Blastic plasmacytoid dendritic cell neoplasm in Jinhua,China:Two case reports  

作　　者：Jia-Wei Cai Meng-Yao Li Wei-Hao Wang Hong-Qi Shi Yi-Hui Yang Jia-Jun Chen 

机构地区：[1]Department of Pathology,Jinhua Hospital,Jinhua 321000,Zhejiang Province,China [2]Department of Pathology,Shaoxing People’s Hospital,Shaoxing 312000,Zhejiang Province,China [3]Department of Urology,Shaoxing People's Hospital,Shaoxing 312000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第22期5263-5270,共8页世界临床病例杂志

摘　　要：BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare and clinically aggressive hematologic malignancy originating from the precursors of plasmacytoid dendritic cells.BPDCN often involves the skin,lymph nodes,and bone marrow,with rapid clinical progression and a poor prognosis.The BPDCN diagnosis is mainly based on the immunophenotype.CASE SUMMARY In this paper,we retrospectively analyzed 2 cases of BPDCN.Both patients were elderly males.The lesions manifested as skin masses.Morphological manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous tissues.Immunohistochemistry staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were positive.CONCLUSION In this paper,we retrospectively analyzed 2 cases of BPDCN.Both patients were elderly males.The lesions manifested as skin masses.Morphological manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous tissues.Immunohistochemistry staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were positive.

关 键 词：Blastic plasmacytoid dendritic cell neoplasm SKIN Clinical pathology IMMUNOPHENOTYPE Hematopoietic stem cell transplantation Case report 

分 类 号：R733[医药卫生—肿瘤]