Link between irritable bowel syndrome,depression,and colorectal cancer risk in young patients:Age-matched nationwide populationbased study  

作　　者：Sai Priyanka Mellacheruvu Sai Prasanna Lekkala Sukhjinder Chauhan Adil Sarvar Mohammed Sravya R Mundla Ankita Shenoy Bilal Khan Mohammed Jerrin Bawa Shantha Nallapothula Priyatham Gurram Akhil Jain Rupak Desai Mohammed Mustafa Nayeem 

机构地区：[1]Department of Public Health,University of Massachusetts,Lowell,MA 01854,United States [2]Department of Internal Medicine,Mamata Medical College,Telangana,Khammam 507002,India [3]Department of Internal Medicine,Mountainview Hospital,Las Vegas,NV 89128,United States [4]Department of Internal Medicine,Central Michigan University College of Medicine,Saginaw,MI 48602,United States [5]Department of Public Health,Apollo Institute of Medical Sciences and Research,Telangana,Hyderabad 500090,India [6]Department of Medicine,Dr D.Y.Patil University School of Medicine,Maharashtra,Navi Mumbai 400706,India [7]Department of Medicine,Northwestern University Feinberg School of Medicine,Chicago,IL 60611,United States [8]Department of Internal Medicine,Flushing Hospital Medical Center,Queens,NY 11355,United States [9]Department of Internal Medicine,PES Institute of Medical Sciences and Research,Andhra Pradesh,Kuppam 517425,India [10]Department of Gastroenterology,Mayo Clinic,Scottsdale,AZ 85259,United States [11]Division of Leukemia,The University of Texas MD Anderson Cancer Center,Houston,TX 77079,United States [12]Independent Researcher,Atlanta,GA 30079,United States [13]Department of Internal Medicine,Parkview Medical Center,Pueblo,CO 81003,United States

出　　处：《World Journal of Gastrointestinal Pathophysiology》2024年第3期1-8,共8页世界胃肠病理生理学杂志（英文版）（电子版）

基　　金：Corresponding Author's Membership in Professional Societies:CHEST,No.2306697.

摘　　要：BACKGROUND There exists a link between irritable bowel syndrome(IBS)and depression.Similarly,chronic depression is known to increase the risk of cancer in general.In this population-based analysis,we investigated the prevalence and the odds of colorectal cancer(CRC)in young-depressed patients with IBS.AIM To investigate the relationship between IBS and CRC in young,depressed patients using a nationally representative United States inpatient sample.METHODS The 2019 National Inpatient Sample was used to identify young(18-44 years)patients admitted with comorbid depression in the presence vs absence of IBS using relevant International Classification of Diseases,Tenth Revision,Clinical Modification codes.Primary endpoint was the prevalence and odds of CRC in age matched(1:1)youngdepressed cohort hospitalized with IBS(IBS+)vs without IBS(IBS-).Multivariable regression analysis was performed adjusting for potential confounders.RESULTS Age-matched(1:1)young-depressed IBS+(83.9%females,median age 36 years)and IBS-(65.8%females,median age 36 years)cohorts consisted of 14370 patients in each group.IBS+cohort had higher rates of hypertension,uncomplicated diabetes,hyperlipidemia,obesity,peripheral vascular disease,chronic obstructive pulmonary disease,hypothyroidism,prior stroke,prior venous thromboembolism,anxiety,bipolar disorder,and borderline personality disorder(P<0.005)vs the IBS-cohort.However,prior myocardial infarction,acquired immunodeficiency syndrome,dementia,smoking,alcohol abuse,and drug abuse(P<0.005)are high in IBS-cohort.The rate of CRC was comparable in both cohorts[IBS+n=25(0.17%)vs IBS-n=35(0.24%)].Compared to the IBS-cohort,the odds ratio(OR)of developing CRC was not significantly higher[OR 0.71,95% confidence interval(CI)0.23-2.25]in IBS+cohort.Also,adjusting for baseline sociodemographic and hospital characteristics and relevant comorbidities,the OR was found to be non-significant(OR 0.89,95%CI 0.21-3.83).CONCLUSION This nationwide propensity-matched analysis revealed comparable prevalence and risk of

关 键 词：Colorectal cancer DEPRESSION Irritable bowel syndrome Young patients National inpatient sample COMORBIDITIES 

分 类 号：R574[医药卫生—消化系统]