Atrial fibrillation and prediabetes:A liaison that merits attention!  

作　　者：Akash Batta Juniali Hatwal 

机构地区：[1]Department of Cardiology,Dayanand Medical College and Hospital,Ludhiana 141001,Punjab,India [2]Department of Internal Medicine,Post Graduate Institute of Medical Education&Research,Chandigarh 160012,India

出　　处：《World Journal of Diabetes》2024年第7期1645-1647,共3页世界糖尿病杂志（英文版）（电子版）

摘　　要：Atrial fibrillation(AF)and prediabetes share common pathophysiological mechanisms with endothelial dysfunction and inflammation playing a key role.The resultant vicious cycle which sets in culminates in a higher atherogenicity and thermogenicity of the vascular system resulting in increased major adverse cardiac or cerebrovascular event(MACCE)events.However,the same has not convincingly been verified in real-world settings.In the recent retrospective study by Desai et al amongst AF patients being admitted to hospitals following MACCE,prediabetes emerged as an independent risk factor for MACCE after adjusting for all confounding variables.However,certain questions like the role of metformin,quantifying the risk for MACCE amongst prediabetes compared to diabetes,the positive impact of reversion to normoglycemia remain unanswered.We provide our insights and give future directions for dedicated research in this area to clarify the exact relationship between the two.

关 键 词：Atrial fibrillation Major adverse cardiac or cerebrovascular event PREDIABETES Diabetes Stroke Heart failure DYSGLYCEMIA METFORMIN 

分 类 号：R541.7[医药卫生—心血管疾病] R587.1[医药卫生—内科学]