Perianal disease in inflammatory bowel disease:Broadening treatment and surveillance strategies for anal cancer  

作　　者：Tatiana Pacheco Sara Monteiro Luísa Barros Jorge Silva 

机构地区：[1]Department of Gastroenterology,Centro Hospitalar do Tamega e Sousa,Penafiel 4560-136,Portugal

出　　处：《World Journal of Gastroenterology》2024年第28期3373-3385,共13页世界胃肠病学杂志（英文版）

摘　　要：The perianal disease affects up to one-third of individuals with Crohn's disease(CD),causing disabling symptoms and significant impairment in quality of life,particularly for those with perianal fistulising CD(PFCD).The collaborative effort between gastroenterologists and surgeons is essential for addressing PFCD to achieve fistula closure and promote luminal healing.Limited fistula healing rates with conventional therapies have prompted the emergence of new biological agents,endoscopic procedures and surgical techniques that show promising results.Among these,mesenchymal stem cells injection is a particularly hopeful therapy.In addition to the burden of fistulas,individuals with perianal CD may face an increased risk of developing anal cancer.This underscores the importance of surveillance programmes and timely interventions to prevent late diagnoses and poor outcomes.Currently,there is no established formal anal screening programme.In this review,we provide an overview of the current state of the art in managing PFCD,including novel medical,endoscopic and surgical approaches.The discussion also focuses on the relevance of establishing an anal cancer screening programme in CD,intending to propose a risk-based surveillance algorithm.The validation of this surveillance programme would be a significant step forward in improving patient care and outcomes.

关 键 词：Inflammatory bowel disease Crohn's disease PERIANAL FISTULA Anus diseases Management Anal cancer SCREENING 

分 类 号：R735.38[医药卫生—肿瘤]