GATIS score for predicting the prognosis of rectal neuroendocrine neoplasms:A Chinese multicenter study of 12-year experience  

作　　者：Xin-Yu Zeng Ming Zhong Guo-Le Lin Cheng-Guo Li Wei-Zhong Jiang Wei Zhang Li-Jian Xia Mao-Jun Di Hong-Xue Wu Xiao-Feng Liao Yue-Ming Sun Min-Hao Yu Kai-Xiong Tao Yong Li Rui Zhang Peng Zhang 

机构地区：[1]Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,Hubei Province,China [2]Department of Gastrointestinal Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]Department of General Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Beijing 100730,China [4]Department of Colorectal Surgery,Fujian Medical University,Fuzhou 350401,Fujian Province,China [5]Department of Colorectal Surgery,Changhai Hospital,Shanghai 200433,China [6]Department of Gastrointestinal Surgery,The First Affiliated Hospital of Shandong First Medical University,Jinan 250118,Shandong Province,China [7]Department of Gastrointestinal Surgery,Taihe Hospital,Hubei University of Medicine,Shiyan 442099,Hubei Province,China [8]Department of Gastrointestinal Surgery I Section,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China [9]Department of General Surgery,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441021,Hubei Province,China [10]Department of Colorectal Surgery,Jiangsu Province Hospital,Nanjing Medical University,Nanjing 210029,Jiangsu Province,China [11]Department of Gastrointestinal Surgery,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [12]Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong Province,China [13]Department of Colorectal Surgery,Liaoning Cancer Hospital,Shenyang 110042,Liaoning Province,China

出　　处：《World Journal of Gastroenterology》2024年第28期3403-3417,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.82072736 and No.81874184;the Key Project of Hubei Health Commission,No.WJ2019Q030.

摘　　要：BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large cohort.METHODS Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in China.Random forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were constructed.RESULTS A total of 1408 patients with R-NENs were included.Tumor grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for prognosis.The GATIS score was calculated based on these five indicators.For overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival prediction.According to decision curve analysis,net benefit of the GATIS score was higher than that of a single factor.The time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time periods.CONCLUSION The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.

关 键 词：Rectal neuroendocrine neoplasm NOMOGRAM Random forest PROGNOSIS Overall survival Progression-free survival 

分 类 号：R730.7[医药卫生—肿瘤]