阿尔茨海默病的影像微生物组学研究进展  

Progress of research on Alzheimer's disease based on radiomicrobiomics

作　　者：刘聪聪 王琰 宋莉[1] 宋民芳 李红芳[1] 丁贝贝 盛灿 LIU Cong-cong;WANG Yan;SONG Li;SONG Min-fang;LI Hong-fang;DING Bei-bei;SHENG Can(The Afiliated Hospital of Jining Medical University,Jining Shandong 272000,China;Department of Neurology,the Hospital of Liangshan Traditional Chinese Medicine,Jining Shandong 272699,China)

机构地区：[1]济宁医学院附属医院,山东济宁272000 [2]梁山县中医院脑病科,山东济宁272699

出　　处：《中国临床医学影像杂志》2024年第7期512-515,共4页Journal of China Clinic Medical Imaging

基　　金：国家自然科学基金(81801052);山东省自然科学基金(ZR2023MH170);泰山学者青年专家项目资助;山东省医药卫生科技发展计划(202203070774);济宁重点研发计划(2022YXNS051)。

摘　　要：肠道菌群失调与阿尔茨海默病(Alzheimer’s disease,AD)的发病密切相关。研究发现,AD连续疾病谱的肠道微生物组成及多样性已发生特征性的改变。然而,有关肠道微生物调控AD患者高级皮层功能的机制仍不清楚。近年来,随着神经影像技术的迅速发展,联合肠道微生物组学与多模态神经影像技术可为深入探索“肠-脑轴”的互作机制提供有效途径。本文就AD的影像微生物组学研究进行综述。Gut dysbiosis is closely associated with the development of Alzheimer's disease(AD).Accumulating evidence has revealed the specific changes of the gut microbial compositions and diversity in the whole spectrum of AD.However,the regulatory mechanisms of the gut microbiota on cognitive function remain unclear.Recently,with the rapid advances of neu-roimaging techniques,the combination of the gut microbiota and multi-modal neuroimaging techniques may provide an effective approach for substantially exploring the interactions of the“gut-brain axis”.In this review,we aim to summarize the progress of radiomicrobiomics in AD.

关 键 词：阿尔茨海默病 胃肠道微生物组 磁共振成像 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]