Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function  

作　　者：Sha Li Nan Zhang Wang Li Han-Lai Zhang Xiao-Xi Wang 

机构地区：[1]Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100000,China [2]Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100000,China

出　　处：《World Journal of Psychiatry》2024年第7期1095-1105,共11页世界精神病学杂志

基　　金：Supported by the National Natural Science Foundation of China,No.82305035.

摘　　要：BACKGROUND Autism spectrum disorder(ASD)is a developmental disorder characterized by social deficits and repetitive behavior.Gastrointestinal(GI)problems,such as constipation,diarrhea,and inflammatory bowel disease,commonly occur in patients with ASD.Previously,GI problems of ASD patients were attributed to intestinal inflammation and vertical mother-to-infant microbiome transmission.AIM To explore whether GI problems in ASD are related to maternal intestinal inflam-mation and gut microbiota abnormalities.METHODS An ASD rat model was developed using valproic acid(VPA).Enzyme-linked immunosorbent assay and fecal 16S rRNA sequencing were used to test GI changes.RESULTS VPA exposure during pregnancy led to pathological maternal intestinal changes,resulting in alterations in maternal gut microbiota.Additionally,the levels of inflammatory factors also increased.Moreover,prenatal exposure to VPA resulted in impaired duodenal motility in the offspring as well as increased levels of infla-mmatory factors.CONCLUSION GI problems in ASD may be associated with maternal intestinal inflammation and microbiota abnormality.Future research is required to find more evidence on the etiology and treatment of GI problems in ASD.

关 键 词：Autism spectrum disorder Gastrointestinal problems Gut microbiota Intestinal inflammation Intestinal motility 

分 类 号：R57[医药卫生—消化系统]