Biophysical cues involved in the stem cell niche for stemness maintenance  

作　　者：Chiyu Li Lisha Zheng Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2024年第2期80-89,共10页医学中新技术与新装备（英文）

基　　金：funded by National Natural Science Foundation of China[grant numbers 32171310,11972067,12332019,U20A20390];Beijing Natural Science Foundation[grant number L234072].

摘　　要：The characteristics of stem cells are self-renewal ability and differentiation potential.These properties are defined as stemness,offering them application in tissue repair and regeneration based on stem cells with great promise.However,stem cells undergo functional deterioration and gradually lose stemness with long-term expansion.Accumulating evidence implies that the regulation of stemness is primarily orchestrated by the niche,which comprises the connection between stem cells and niche cells,extracellular matrix(ECM)proteins,and secreted factors.Increasingly,physical signals are being acknowledged as paramount regulators of cellular behavior,governing stem cell stemness,tissue development,and regeneration.This review outlines current approaches for stemness maintenance and the important biophysical cues involved in the stem niche.We first encompass the latest discoveries regarding the sources and transduction pathways of these biophysical cues.Subsequently,the specific biophysical factors for regulating stemness have been described.Moreover,we summarize existing challenges and prospect future research in this field.

关 键 词：STEMNESS Stem cell BIOPHYSICAL NICHE 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]