Shifts in intrinsic neural timescale of hippocampus support the maturation of inhibitory control and working memory in youth  

作　　者：Debin Zeng Qiongling Li Deyu Li Shuyu Li 

机构地区：[1]Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science&Medical Engineering,Beihang University,Beijing,100083,China [2]State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing,100875,China [3]Beijing Key Laboratory of Brain Imaging and Connectomics,Beijing Normal University,Beijing,100875,China [4]IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing,100875,China [5]State Key Laboratory of Virtual Reaility technology and Systems,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2024年第2期115-123,共9页医学中新技术与新装备（英文）

基　　金：Shuyu Li is supported by the National Natural Science Foundation of China(32271146);the Startup Funds for Top-notch Talents at Beijing Normal University。

摘　　要：The intrinsic neural timescale(INT)provides temporal windows in brain activity that process information of different durations,crucial for the integration and segregation of external inputs and ultimately shaping cognition and behavior.Recent research has uncovered a pronounced INT hierarchy along the adult hippocampus's longaxis.Yet,the development of INT organization within the hippocampus—particularly the pattern of its hierarchical structure and its impact on cognitive development—has not been thoroughly investigated in youth.Here,we discovered that the INT distribution in youth presents a distinct hierarchical structure along both posterioranterior and proximal-distal axes of the hippocampus.Strikingly,this hierarchical structure correlates signifi-cantly with the first principal gradient of the hippocampal-cortical functional connectome and the thickness of hippocampal grey matter.Furthermore,we observed notable changes in the hippocampal INT landscape during youth,characterized by a general narrowing of timescales,alongside dedifferentiation along the hippocampal organizational axes.These maturational changes significantly link to improvements in inhibitory control and working memory performance.Collectively,our findings reveal the developmental patterns of temporal integration and segregation hierarchies within hippocampus,and highlights the profound significance of INT as a neural underpinning that orchestrates cognitive growth.

关 键 词：Intrinsic neural timescale HIPPOCAMPUS Development Inhibitory control and working memory 

分 类 号：R338[医药卫生—人体生理学]