从子午流注学说探讨多囊卵巢综合征的治疗  

Discussion on the Treatment of PCOS Based on Midnight-Noon Ebb-Flow Theory

作　　者：郭倩 陈婕 李晓欣 彭尧 谈勇[1] GUO Qian;CHEN Jie;LI Xiaoxin;PENG Yao;TAN Yong(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Reproductive Medicine Department,Linyi People’s Hospital,Linyi 276007,China;The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]临沂市人民医院生殖医学科,山东临沂276007 [3]西南医科大学附属中医医院,四川泸州646000

出　　处：《南京中医药大学学报》2024年第7期661-667,共7页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金重点项目(82330125)。

摘　　要：基于子午流注学说探讨多囊卵巢综合征(PCOS)的治疗。子午流注学说是将自然界的时间、空间与人体内在节律相结合的中医时间医学。PCOS以生殖月节律的消失为主要特征,病机以肾虚为本,阴盛而阳虚、阳亢而阴虚、阴阳气不相顺接是其病机关键。PCOS患者昼夜节律紊乱,核心时钟基因的振荡衰减,导致卵巢中的昼夜节律基因定时中断,肾中阴阳转化失衡,气血流注与时间节律不同步,故治疗重在燮理阴阳,重建女性正常的生殖节律。运用子午流注学说,结合女性生殖生理特点,选择不同的给药时间及按时辰值经取穴,有助于解开女性生殖系统的“时间密码”,帮助临床调经种子助孕及治未病。This paper discusses the treatment of polycystic ovary syndrome(PCOS)based on the midnight-noon ebb-flow theory.The midnight-noon ebb-flow theory is a Chinese medicine science that combines the time and space of nature with the internal rhythm of the human body.PCOS is characterized by disappearance of the reproductive monthly rhythm.Its etiology is based on kidney deficiency.The key to its pathogenesis is the excess of yin and deficiency of yang,the hyperactivity of yang and deficiency of yin,and the lack of smooth connection between yin and yang.PCOS patients have circadian rhythm disorders,and the oscillation of the core clock gene is attenuated,which leads to the interruption of the circadian rhythm gene in the ovary,the imbalance of yin and yang transformation in the kidney,and the asynchrony of qi and blood flow with the time rhythm.Therefore,the treatment focuses on harmonizing yin and yang and rebuilding the normal reproductive rhythm of women.Using the midnight-noon ebb-flow theory,combined with the reproductive physiological characteristics of women,choosing different drug administration time and selecting meridians and acupoints according to the time will be helpful to unlock the"time code"of the female reproductive system,and assist clinical menstruation regulation,pregnancy and treatment of diseases.

关 键 词：多囊卵巢综合征 子午流注学说 生物节律 肾虚 阴阳 

分 类 号：R224.3[医药卫生—中医基础理论]