Tacrolimus combined with arsenic trioxide provides a three-in-one drug-eluting coronary stent integrating anti-restenosis,pro-endothelialization and anti-inflammation  

作　　者：Yaojia Zhang Hongchi Yu Li Deng Zhe Hou Jie Yang Fei Fang Michael ZMiao Wenjun Li Xin Shen Dongyun Hao Xiaoyi Ma Lifeng Zhou Fugui He Xiaoheng Liu 

机构地区：[1]a1Institute of Biomedical Engineering,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu,610041,China [2]Division of Oral&Craniofacial Health Sciences,Adams School of Dentistry,University of North Carolina at Chapel Hill,NC,27599,USA [3]Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine,Beijing,100021,China

出　　处：《Medicine in Novel Technology and Devices》2024年第1期110-119,共10页医学中新技术与新装备（英文）

基　　金：National Natural Science Foundation of China(11932014,31971239);Sichuan Science and Technology Program(2022NSFSC0765,2022ZYD0079).

摘　　要：The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation,which often leads to inflammation,call for innovative approaches in coronary artery disease treatment.In the present work,we propose a revolutionary solution:a three-in-one platform for vascular stents,combining arsenic trioxide(ATO)and tacrolimus(TAC)to address anti-proliferation,pro-endothelialization,and anti-inflammation aspects.Our findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell inflammation.Remarkably,the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion abilities.Moreover,our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation model.Both in vitro and in vivo results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent restenosis.Overall,this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.

关 键 词：TACROLIMUS Arsenic trioxide Drug-eluting stent 

分 类 号：R318[医药卫生—生物医学工程]