N-亚硝基二甲胺的危害评估  

Hazard assessment of the dimethylnitrosamine

作　　者：傅欣磊 宁钧宇[1,2] FU Xin-lei;NING Jun-yu(School of Public Health,Capital Medical University,Beijing 100069,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]北京市疾病预防控制中心,北京100013

出　　处：《毒理学杂志》2024年第3期193-198,206,共7页Journal of Toxicology

基　　金：北京市高层次公共卫生技术人才建设项目。

摘　　要：目的开展N-亚硝基二甲胺的危害评估,估算可接受摄入水平。方法采用系统文献检索方法,收集N-亚硝基二甲胺毒理学资料,对NDMA进行危害识别和危害特征描述,并估算慢性每日摄入量(chronic daily intake,CDI)的可接受水平。结果基于NDMA的致癌强度和人群癌症风险基线水平估算得到的NDMA的慢性可接受摄入水平为不超过0.02 ng/kg·bw/d。结论提出的NDMA CDI值可为人群风险评估提供参考。Objective To assess the hazard of N-nitrosodimethylamine and estimate the acceptable intake level.Methods The toxicological data of N-nitrosodimethylamine were collected by systematic literature search.Hazard identification and hazard characteristics of NDMA were described,and the acceptable level of chronic daily intake(CDI)was estimated.Results Based on the carcinogenic intensity of NDMA and the baseline population risk of cancer,the chronic acceptable intake level of NDMA was not more than 0.02ng/kg·bw/d by estimating.Conclusion The CDI of NDMA can be used as a reference for population risk assessment.

关 键 词：二甲基亚硝胺 危害评估 食品安全 

分 类 号：R114[医药卫生—卫生毒理学] R99[医药卫生—公共卫生与预防医学]