低强度激光联合口腔正畸对牙周病致前牙移位患者疼痛及龈沟液ALP、AST、sICAM-1水平的影响  

Effect of low-intensity laser combined with orthodontic treatment on pain and ALP,AST,and sICAM-1 in patients with anterior tooth displacement caused by periodontal disease

作　　者：王冠超[1] 马俐丽[1] 李丹[1] 陈超[1] 孙强[1] WANG Guan-chao;MA Li-li;LI Dan;CHEN Chao;SUN Qiang(Stomatology Center,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院口腔医学中心,北京100029

出　　处：《川北医学院学报》2024年第7期892-895,共4页Journal of North Sichuan Medical College

基　　金：北京市自然科学基金(4242014)。

摘　　要：目的:探讨低强度激光联合口腔正畸对牙周病致前牙移位患者疼痛及龈沟液中碱性磷酸酶(ALP)、天门冬氨酸氨基转移酶(AST)、可溶性细胞间粘附分子-1(sICAM-1)水平的影响。方法:选取89例牙周病致前牙移位患者为研究对象,根据治疗方式不同分为对照组(n=44)与研究组(n=45)。对照组患者接受口腔正畸治疗;研究组患者在对照组基础上联合低强度激光治疗,两组患者疗程均为3个月。比较两组患者各时间点疼痛情况[视觉模拟评分(VAS)]、牙齿移动距离、牙齿回缩速度、牙齿松动度及龈沟液中ALP、AST、sICAM-1水平。结果:治疗后2、4、24 h及3 d,研究组患者VAS评分均低于对照组(P<0.05)。治疗后7、14、28 d及3个月,研究组患者牙齿移动距离均高于对照组(P<0.05)。治疗后7、14、28 d,研究组患者牙齿回缩速度均高于对照组(P<0.05)。治疗后3个月,两组患者龈沟液中ALP、AST、sICAM-1表达水平均升高,且研究组低于对照组(P<0.05)。结论:在口腔正畸的基础上联合低强度激光治疗有利于加速牙周病致前牙移位牙齿移动,可有效缓解疼痛及牙周炎性反应。Objective:To investigate the effect of low-intensity laser combined with orthodontic treatment on pain and levels of ALP,AST,and sICAM-1 in gingival crevicular fluid in patients with anterior tooth displacement caused by periodontal disease.Methods:89 patients with anterior tooth displacement caused by periodontal disease were selected.They were divided into control group(n=44)and study group(n=45)according to the treatment methods.The control group received orthodontic treatment,while the study group received low-intensity laser treatment in combination with the control group,and both groups had a course of 3 months.The pain status[visual analog scale(VAS)score],tooth movement distance,tooth retraction speed,tooth looseness,and levels of ALP,AST,and sICAM-1 in gingival crevicular fluid were compared between two groups.Results:At 2 h,4 h,24 h,and 3 d after treatment,the VAS of the study group was lower than that of the control group(P<0.05).After 7 d,14 d,28 d,and 3 m of treatment,the tooth movement distance of the study group was higher than that of the control group(P<0.05).At 7,14,and 28 d after treatment,the tooth retraction speed of the study group was overtop than that of the control group(P<0.05).After 3 months of treatment,the expression levels of ALP,AST,and sICAM-1 in the gingival crevicular fluid of both groups increased compared to before treatment,but the study group was lower than the control group(P<0.05).Conclusion:Combining low intensity laser therapy with orthodontic treatment is beneficial for accelerating anterior tooth displacement and movement caused by periodontal disease,and can effectively alleviate pain and periodontal inflammatory reactions.

关 键 词：低强度激光 口腔正畸 牙周病致前牙移位 疼痛 炎性反应 

分 类 号：R783.5[医药卫生—口腔医学]