C1q肿瘤坏死因子相关蛋白9与急性缺血性脑卒中患者全因死亡及卒中复发的关系研究  

Relationship between C1q/TNF-Related Protein 9 and All-Cause Mortality and Stroke Recurrence in Patients with Acute Ischemic Stroke

作　　者：赵锦程[1] 王星[2] 李起超[1] 彭晓辉 安明华 吴磊[1] 王永恒[1] ZHAO Jincheng;WANG Xing;LI Qichao;PENG Xiaohui;AN Minghua;WU Lei;WANG Yongheng(Department of Neurosurgery Ward 2,Qinhuangdao First Hospital,Qinhuangdao 066300,China;Department of Endocrinology Ward 2,Qinhuangdao First Hospital,Qinhuangdao 066300,China;Department of External Medicine 1,Hebei Veterans General Hospital,Xingtai 054000,China;Department of Ultrasound,Qinhuangdao Haigang Hospital,Qinhuangdao 066300,China)

机构地区：[1]河北省秦皇岛市第一医院神经外科二病区,066300 [2]河北省秦皇岛市第一医院内分泌科二病区,066300 [3]河北省退役军人总医院外一科,河北省邢台市054000 [4]河北省秦皇岛市海港医院超声科,066300

出　　处：《实用心脑肺血管病杂志》2024年第8期43-47,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：河北省卫健委医学科学研究项目(20191377);秦皇岛市科技局自筹项目(202301A104)。

摘　　要：目的探讨C1q肿瘤坏死因子相关蛋白9(CTRP9)与急性缺血性脑卒中(AIS)患者全因死亡及卒中复发的关系。方法回顾性选取2020年1月—2021年6月在秦皇岛市第一医院住院的AIS患者367例为研究对象。收集患者临床资料,出院后第3、12、24个月通过门诊复查或电话随访收集患者全因死亡和卒中复发情况。采用多因素Cox比例风险回归分析探讨AIS患者全因死亡和卒中复发的影响因素。结果367例AIS患者中,随访期间死亡20例(5.4%),卒中复发45例(12.3%)。生存与死亡者年龄、有心房颤动史者占比、有冠心病史者占比、TOAST分型、入院时美国国立卫生研究院卒中量表(NIHSS)评分、出院时NIHSS评分、入院时改良Rankin量表(mRS)评分、出院时mRS评分、中性粒细胞计数、红细胞体积分布宽度(RDW)、CTRP9比较,差异有统计学意义(P<0.05)。卒中复发与非卒中复发者有卒中史者占比、有冠心病史者占比、TOAST分型比较,差异有统计学意义(P<0.05)。多因素Cox比例风险回归分析结果显示,年龄〔HR=1.073,95%CI(1.020~1.128)〕、冠心病史〔HR=6.572,95%CI(1.700~25.406)〕、CTRP9〔HR=1.008,95%CI(1.001~1.015)〕是AIS患者全因死亡的独立影响因素,冠心病史〔HR=4.949,95%CI(2.047~11.964)〕是AIS患者卒中复发的独立影响因素(P<0.05)。结论CTRP9是AIS患者全因死亡的独立影响因素,尚未发现CTRP9是AIS患者卒中复发的独立影响因素。Objective To investigate the relationship between C1q/TNF-related protein 9(CTRP9)and all-cause mortality and stroke recurrence in patients with acute ischemic stroke(AIS).Methods A total of 367 patients with AIS admitted to Qinhuangdao First Hospital from January 2020 to June 2021 were retrospectively selected as the research subjects.The clinical data of the patients were collected,all-cause mortality and stroke recurrence of patients were collected through outpatient followup or telephone follow-up at 3,12,and 24 months after discharge.Multivariate Cox proportional risk regression analysis was used to explore the influencing factors of all-cause mortality and stroke recurrence in patients with AIS.Results Among 367 AIS patients,20(5.4%)suffered from death during follow up and 45(12.3%)suffered from stroke recurrence.There were significant differences in age,proportion of patients with atrial fibrillation history,proportion of patients with coronary artery disease history,TOAST classification,National Institute of Health Stroke Scale(NIHSS)score at admission,NIHSS score at discharge,modified Rankin Scale(mRS)score at admission,mRS score at discharge,neutrophil count,red cell distribution width(RDW),CTRP9 between patients with survival and death(P<0.05).There were significant differences in proportion of patients with stroke history,proportion of patients with coronary artery disease history,TOAST classification between patients with stroke recurrence and nonstroke recurrence(P<0.05).Multivariate Cox proportional risk regression analysis showed that age[HR=1.073,95%CI(1.020-1.128)],coronary artery disease history[HR=6.572,95%CI(1.700-25.406)],CTRP9[HR=1.008,95%CI(1.001-1.015)]were the independent influencing factors of all-cause mortality in patients with AIS,coronary artery disease history[HR=4.949,95%CI(2.047-11.964)]was the independent influencing factor of stroke recurrence in patients with AIS(P<0.05).Conclusion CTRP9 is the independent influencing factor of all-cause mortality in patients with AIS,and it h

关 键 词：缺血性卒中 C1q肿瘤坏死因子相关蛋白9 死亡 复发 

分 类 号：R743.3[医药卫生—神经病学与精神病学]