微小RNA调控脑缺血再灌注损伤炎症反应机制的研究进展  

Research Progress on the Mechanism of miRNA Regulating Inflammatory Response in Cerebral Ischemia-Reperfusion Injury

作　　者：王坤鹏 卢志刚 WANG Kunpeng;LU Zhigang(Medical School,Hubei Minzu University,Jingmen 448000,China;Department of Neurology,Jingmen Central Hospital,Jingmen 448000,China;Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases,Enshi 445000,China)

机构地区：[1]湖北民族大学附属医学部,湖北省荆门市448000 [2]湖北省荆门市中心医院神经内科,448000 [3]风湿性疾病发生与干预湖北省重点实验室,湖北省恩施市445000

出　　处：《实用心脑肺血管病杂志》2024年第8期136-140,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(82060813);湖北省卫生健康委员会科研项目(WJ2021M075);湖北省荆门市科技计划重点项目(2022YFZD021)。

摘　　要：脑缺血再灌注损伤(CIRI)指脑缺血一段时间后血流恢复,细胞凋亡、炎症反应、氧化应激、自噬等机制导致脑组织损伤更加严重的病理现象。相关研究表明,微小RNA(miRNA)作为调控炎症因子的重要递质,在CIRI病理过程中起到了至关重要的作用。本文揭示了miRNA调控CIRI炎症反应的机制,并指出促进或抑制miRNA的表达可减轻CIRI。Cerebral ischemia-reperfusion injury(CIRI)refers to a pathological phenomenon in which blood flow is restored after cerebral ischemia for a period of time,resulting in more serious brain tissue damage due to mechanisms such as cell apoptosis,inflammatory response,oxidative stress,and autophagy.Relevant studies have shown that microRNA(miRNA),as an important mediator in regulating inflammatory factors,plays a crucial role in the pathological process of CIRI.This review reveals the mechanism of miRNA regulates inflammatory response in CIRI,and points out that promoting or inhibiting the expression of miRNA can reduce CIRI.

关 键 词：再灌注损伤 脑血管损伤 微RNAS 炎症因子 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]