化学遗传学技术在抑郁症神经环路研究中的应用  

Application of chemogenetic technology in the study of neural circuits in depression

作　　者：李绍炜 李节惠 张明宽 张浩 胡明会 陈丹 徐凯勇 李自发 耿希文 魏盛 Li Shaowei;Li Jiehui;Zhang Mingkuan;Zhang Hao;Hu Minghui;Chen Dan;Xu Kaiyong;Li Zifa;Geng Xiwen;Wei Sheng(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shengli Oil Field Central Hospital,Dongying 257000,China;Key Laboratory of Traditional Chinese Medicine Classical Theory(Ministry of Education),Chinese Medicine and Brain Science Interdisciplinary Research Institute,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]胜利油田中心医院,东营257000 [3]山东中医药大学中医药经典理论教育部重点实验室,山东中医药大学中医药与脑科学交叉学科研究平台,济南250355

出　　处：《中华行为医学与脑科学杂志》2024年第6期554-559,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(82274383);泰山学者工程专项经费资助项目(TSQN202211137)。

摘　　要：化学遗传学技术是一种通过改变受体特异性和亲和力来调节细胞活性与功能的受体-配体系统的技术,其通过特异性地调控神经元及神经环路精准调控神经。目前,该技术在神经环路研究中应用十分广泛。本文主要简述化学遗传学技术在抑郁症神经环路研究中的应用与进展,梳理该技术在腹侧被盖区、伏隔核、前额叶皮质、海马、外侧缰核等几个与抑郁症发生密切相关的脑区中的应用,讨论化学遗传学技术作为一种精准调控神经活动的技术在未来研究中的潜力和挑战,以期为化学遗传学技术在抑郁症神经环路研究提供可靠的思路和方向。Chemogenetic technology is a receptor-ligand system that regulates cell viability and function by changing receptor specificity and affinity,and it achieves precise neuronal regulation by specifically regulating neurons and neural circuits.At present,this technique is widely used in the study of neural circuits.This article briefly describes the application and progress of chemogenetic technology in the study of depression neural circuits,reviews the application of chemogenetic technology in several brain regions closely related to depression,such as ventral tegmental area,nucleus accumbens,prefrontal cortex,hippocampus and lateral habenula,and discusses the potential and challenges of chemogenetic technology as a technology for precise regulation of neural activity in future research,in order to provide reliable ideas and directions for chemogenetic technology in the study of depression neural circuits.

关 键 词：化学遗传学技术 神经环路 抑郁症 神经调控 

分 类 号：R749.4[医药卫生—神经病学与精神病学]