神经黏附分子65在中枢神经系统中的作用  

Role of neuroplastin 65 in the central nervous system

作　　者：徐黎[1] 张伟[1] 马正良[1] Xu Li;Zhang Wei;Ma Zhengliang(Department of Anesthesiology,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,南京210008

出　　处：《中华行为医学与脑科学杂志》2024年第6期572-576,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81870875)。

摘　　要：神经黏附分子65(neuroplastin 65,NP65)是一类特异性表达于神经元的糖蛋白,广泛分布于中枢神经系统突触膜上,在细胞黏附及细胞间通信中起重要作用。相较于其他细胞黏附分子,NP65的发现较晚,针对NP65研究还在不断发展中,其参与的病理生理机制仍需进一步探索和研究。目前已证实NP65在突触形成和维持、突触可塑性调节、神经元发育等神经活动中发挥关键作用,并且参与多种疾病的发生和发展。因此,NP65可能是调节神经系统发育和功能的重要靶点。本文围绕NP65的结构、分布、功能、参与各类生理病理进程的研究进展予以综述,并提出未来NP65的研究方向,以期增进对NP65功能的理解,更全面地揭示其在疾病中的作用机制,为发展与其相关的临床应用提供理论基础。Neuroplastin 65(NP65)is a glycoprotein class with selective expression in neurons.It is extensively expressed in the synaptic membrane of the central nervous system,and plays a fundamental role in cell adhesion and intercellular communication.In comparison to other cell adhesion molecules,the discovery of NP65 is relatively late and researches about this molecule are still in development.Further exploration and study of the pathophysiological mechanism involved in NP65 are needed.It has been confirmed that NP65 plays a pivotal role in neural activities,including regulation of synaptic formation and maintenance,modulation of synaptic plasticity,facilitation of neuronal development,and contribution to the pathogenesis of various diseases.Thus,NP65 could potentially serve as a crucial target for modulating the growth and operation of the nervous system.This paper provides a comprehensive review of the structure,distribution,function,and involvement in both physiological and pathological processes of NP65.Additionally,the future research direction for NP65 is proposed,with the aim of enhancing our understanding of its function,revealing its mechanism of action in diseases,and providing a theoretical basis for the development of related clinical applications.

关 键 词：神经黏附分子65 中枢神经系统 突触可塑性 病理生理 

分 类 号：R741[医药卫生—神经病学与精神病学]