预后营养指数评估宫颈癌放疗患者急性放射性肠炎发生效果  

Prediction effect of the prognostic nutrition index value for the acute radiation enteritis of patients with cervical cancer radiotherapy

作　　者：刘玉平 张震 王瑜 常娟娟 王光明 LIU Yuping;ZHANG Zhen;WANG Yu;CHANG Juanjuan;WANG Guangming(Fuyang Cancer Hospital,Fuyang,Anhui Province,236048)

机构地区：[1]安徽省阜阳市肿瘤医院,236048

出　　处：《中国计划生育学杂志》2024年第7期1635-1639,共5页Chinese Journal of Family Planning

基　　金：2020年安徽省自然科学基金项目(2020085MH251)。

摘　　要：目的分析预后营养指数(PNI)对宫颈癌放疗患者急性放射性肠炎发生的预测效果。方法:纳入本院2020年1月-2023年8月收治的80例宫颈癌患者临床资料,按照患者放疗后急性放射性肠炎发生情况分别纳入发生组、未发生组,对比两组病理分型、临床分期、PNI等临床资料,使用logistic多因素模型归纳影响患者发生急性放射性肠炎的相关因素;利用受试者工作特征(ROC)曲线分析PNI预测宫颈癌放疗患者急性放射性肠炎发生效能。结果:80例患者中发生急性放射性肠炎17例,发生率为21.3%;患者临床症状以1~2级腹泻、1~2级腹痛为主。logistic多因素回归分析,体质指数<18.5 kg/m^(2)、FIGO分期III~IV期、淋巴结转移、血红蛋白<110 g/L、PNI<48.84均为影响宫颈癌放疗患者急性放射性肠炎的独立危险因素(P<0.05);ROC曲线分析,PNI预测宫颈癌放疗患者急性放射性肠炎的曲线下面积为0.875,灵敏度88.3%、特异性87.3%。结论:PNI能够为宫颈癌放疗患者急性放射性肠炎的预测提供可靠参考。Objective: To analyze the predictive effect Prediction effect of the prognostic nutrition index(PNI) value for the acute radiation enteritis of patients with cervical cancer and radiotherapy. Methods: The clinical data of 80 patients with cervical cancer admitted to the hospital from January 2020 to August 2023 were included in this study. According to the occurrence of the acute radiation enteritis after radiotherapy, these patients were divided into group A(patients with acute radiation enteritis) and group B(patients without acute radiation enteritis). The clinical data, such as the pathological classification, the clinical stage of cervical cancer and the PNI value of the patients were compared between the two groups. Logistic multivariate model was used to analyze the related factors affecting the occurrence of the acute radiation enteritis of the patients. Receiver operating characteristic(ROC) curve was used to analyze the efficacy of the PNI value of the patients for predicting the occurrence of their acute radiation enteritis. Results: Among 80 patients, there were 17 patients with acute radiation enteritis, with an incidence of 21.3%. The clinical symptoms of the patients were mainly the grade 1-2 diarrhea and the grade 1-2 abdominal pain. Logistic multivariate regression analysis showed that the body mass index(BMI) <18.5 kg/m^(2), the FIGO stage III-IV, the lymph node metastasis, the hemoglobin(Hb) <110 g/L, and the PNI value <48.84 of the patients were all the independent risk factors affecting the occurrence of their acute radiation enteritis(P<0.05). ROC curve showed that the area under the curve(AUC), the sensitivity and the specificity of the PNI value of the patients for predicting their acute radiation enteritis were 0.875, 88.3% and 87.3%, respectively. Conclusion: The PNI value of the patients with cervical cancer and radiotherapy can provide a reliable reference for predicting their acute radiation enteritis occurrence.

关 键 词：宫颈癌 放疗 急性放射性肠炎 预后营养指数 影响因素 预测 

分 类 号：R737.33[医药卫生—肿瘤]