刺五加注射液在脑卒中后认知障碍患者治疗中的应用效果分析  

Analysis of the application effect of Ciwujia injection in the treatment of cognitive impairment patients after stroke

作　　者：王小云 Wang Xiaoyun(Psychiatric Department,The People's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong,Yunnan 675000,China)

机构地区：[1]云南省楚雄彝族自治州人民医院,云南楚雄675000

出　　处：《首都食品与医药》2024年第12期161-163,共3页Capital Food Medicine

摘　　要：目的探讨刺五加注射液在脑卒中后认知障碍患者治疗中的应用效果。方法采用随机分配法将2021年6月-2023年3月在楚雄彝族自治州人民医院确诊的106例脑卒中后认知障碍患者分为对照组(n=53)和观察组(n=53)。两组患者均给予常规治疗和康复训练,对照组给予盐酸多奈哌齐片治疗,观察组在对照组的基础上加用刺五加注射液。采用简易智力状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估两组患者治疗前后的认知功能水平,比较两组神经营养因子[脑源性神经营养因子(BDNF)和神经生长因子(NGF)]、生活自理能力及不良反应。结果治疗后,观察组患者MMSE评分、MoCA评分均显著高于对照组(P<0.05)。治疗后,两组患者BDNF、NGF水平均升高,且观察组高于对照组(P<0.05)。治疗后,观察组患者生活自理能力明显优于对照组(P<0.05)。治疗后,观察组患者HAMA评分、HAMD评分均低于对照组(P<0.05)。观察组不良反应发生率(3.8%)低于对照组(17.0%),差异有统计学意义(P<0.05)。结论刺五加注射液在脑卒中后认知障碍患者中的应用效果显著,可有效促进神经营养因子分泌,改善患者认知功能和生活质量,缓解焦虑抑郁状态,且安全性良好。Objective To explore the application effect of Ciwujia injection in the treatment of cognitive impairment patients after stroke.Methods 106 patients with post-stroke cognitive impairment diagnosed in The People's Hospital of Chuxiong Yi Autonomous Prefecture from June 2021 to March 2023 were randomly assigned to a control group(n=53)and an observation group(n=53).Both groups of patients were given routine treatment and rehabilitation training,while the control group was treated with donepezil hydrochloride tablets,while the observation group received Ciwujia injection on top of the control group.The cognitive function levels of two groups of patients before and after treatment were evaluated using the Simplified Mental State Examination(MMSE)and the Montreal Cognitive Assessment Scale(MoCA),and the neurotrophic factors[brain derived neurotrophic factors(BDNF)and nerve growth factor(NGF)],self-care ability,and adverse reactions were compared between the two groups.Results After treatment,the MMSE score and MoCA score of the observation group were significantly higher than those of the control group(P<0.05).After treatment,the levels of BDNF and NGF in both groups of patients increased,and the levels of BDNF and NGF in the observation group were higher than those in the control group(P<0.05).After treatment,the self-care ability of the observation group patients was significantly better than that of the control group(P<0.05).After treatment,the HAMA score and HAMD score of the observation group were lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group(3.8%)was lower than that in the control group(17.0%),with a statistically significant difference(P<0.05).Conclusion The application effect of Ciwujia injection in patients with cognitive impairment after stroke is significant,which can effectively promote the secretion of neurotrophic factors,improve cognitive function and quality of life of patients,alleviate anxiety and depression,and has good safety.

关 键 词：刺五加注射液 脑卒中 认知障碍 生活质量 不良反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]