中国成人急性淋巴细胞白血病诊断与治疗指南(2024年版)  

Chinese guideline for diagnosis and treatment of adult acute lymphoblastic leukemia (2024)

作　　者：中国抗癌协会血液肿瘤专业委员会 中华医学会血液学分会白血病淋巴瘤学组 王建祥 秘营昌 王迎 Hematology Oncology Committee,Chinese Anti-Cancer Association;Leukemia&Lymphoma Group,Chinese Society of Hematology,Chinese Medical Association;Wang Jianxiang;Mi Yingchang(不详;Institute of Hematology&Blood Disease Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)

机构地区：[1]不详 [2]中国医学科学院血液病医院(中国医学科学院血液学研究所),天津300020 [3]中国医学科学院血液病医院

出　　处：《中华血液学杂志》2024年第5期417-429,共13页Chinese Journal of Hematology

摘　　要：成人急性淋巴细胞白血病(ALL)是成人最常见的急性白血病之一, 目前国际上有比较统一的诊断标准和不同研究组报道的系统治疗方案。我国自2013年至今发表了三版中国成人ALL诊断与治疗的专家共识/指南, 对该病种诊断治疗水平提升有重要意义。2022年WHO造血与淋巴组织肿瘤分类对ALL(前体淋巴细胞肿瘤——淋巴母细胞白血病/淋巴瘤)的分类进行了更新, 提出了一些新概念;近年来免疫治疗快速发展, 在一定程度上提高了成人ALL的疗效, 且抗体、嵌合抗原受体T细胞(CAR-T细胞)产品陆续在国内上市, 临床实践日益丰富。为促进成人ALL临床诊疗的规范, 本指南参考国内外最新指南和文献, 荟萃国内外最新研究成果, 为成人ALL的诊断、治疗、疗效监测提供参考意见。Adult acute lymphoblastic leukemia(ALL)is one of the most common acute leukemia in adults.There are relatively unified diagnostic criteria and systematic treatment regimens reported by different research groups in the world.Since 2013,three versions of expert consensus/guidelines on the diagnosis and treatment of adult ALL in China have been published,which are of great significance for improving the level of diagnosis and treatment of this disease.In 2022,the classification of ALL(precursor lymphocyte neoplasms-lymphoblastic leukemias/lymphomas)had been updated in the WHO classification of haematolymphoid tumors,and some new concepts had been proposed.In recent years,the rapid development of immunotherapy has improved the efficacy of adult ALL,and commercial antibodies and CAR-T cell products have been available in China,the clinical practice is increasing.In order to promote the standardization of clinical diagnosis and treatment of adult ALL,by referring to the latest guidelines and literatures all over the world,this guideline may contribute to the better understanding of diagnosis,treatment and efficacy monitoring for adult ALL.

关 键 词：白血病 淋巴细胞 急性 成人 诊断 治疗 疗效监测 

分 类 号：R733.71[医药卫生—肿瘤]