阿尔茨海默病外周血新型生物标志物研究进展  

Recent advance in novel biomarkers in peripheral blood of Alzheimer's disease

作　　者：张丹丹 任国强[2] 吴晶 魏伟 李学忠[1] 陈晓鹏[1] Zhang Dandan;Ren Guoqiang;Wu Jing;Wei Wei;Li Xuezhong;Chen Xiaopeng(Department of Neurology,Affiliated People's Hospital of Jiangsu University,Zhenjiang 212000,China;Department of Radiology,Affiliated People's Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属人民医院神经内科,镇江212000 [2]江苏大学附属人民医院放射科,镇江212000

出　　处：《中华神经医学杂志》2024年第5期513-519,共7页Chinese Journal of Neuromedicine

基　　金：江苏大学附属人民医院院级科研项目(Y2021018)。

摘　　要：阿尔茨海默病(AD)是一种神经退行性疾病,主要表现为进行性记忆缺陷和认知功能下降。既往关于AD外周血生物标志物的研究多集中于病理标志物如β-淀粉样蛋白(Aβ)和磷酸化tau蛋白(p-tau)的改变上。本文围绕近几年AD外周血新型生物标志物如炎性因子、代谢指标、非编码RNA等的研究进展进行综述,以期为AD的诊断提供参考。Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive memory deficits and cognitive decline.Previous studies of peripheral blood biomarkers in AD have been focused on alterations ofβ-amyloid(Aβ)and phosphorylated(p)-tau.This article reviews the research progress of new biomarkers,such as inflammatory factors,metabolic indicators,and non-coding RNA,in peripheral blood of AD in recent years,in order to provide references for AD diagnosis.

关 键 词：阿尔茨海默病 外周血 新型生物标志物 

分 类 号：R749.16[医药卫生—神经病学与精神病学]