宫颈微腺体增生临床病理分析  

Cervical microglandular hyperplasia:Clinical and pathological analysis

作　　者：邓晓 邱莎莎 DENG Xiao;QIU Shasha(Department of Pathology,the First Affiliated Hospital of Gannan Medical University,Jiangxi Ganzhou 341000,China;Department of Basic Medical,Gannan Medical University,Jiangxi Ganzhou 341000,China)

机构地区：[1]赣南医科大学第一附属医院病理科,江西赣州341000 [2]赣南医科大学基础医学院,江西赣州341000

出　　处：《现代肿瘤医学》2024年第13期2411-2414,共4页Journal of Modern Oncology

摘　　要：目的:探讨宫颈微腺体增生临床病理特征、诊断及鉴别诊断,提高临床对该病的认识。方法:回顾性分析2例宫颈微腺体增生患者的临床资料、影像学表现、病理组织形态特点、免疫组化标记特征、预后,并复习国内外相关文献。结果:宫颈微腺体增生临床少见,常表现为息肉样新生物,病理学特征为微小腺体增生,可伴有不典型增生,并见细胞实性增生及印戒样细胞,伴较多炎细胞浸润,结合病理组织形态学特点及免疫组化标记特征,可以明确诊断及鉴别诊断。该文报道2例患者均无口服避孕药史,月经正常,大体均表现为宫颈新生物,影像学检查与宫颈癌难以鉴别,免疫组化表达CK、CK7、CK8、CK5/6、VIM,不表达p16、p63、p40、CEA,p53为野生型,Ki-67增殖指数低。结论:宫颈微腺体增生属于少见的良性占位性病变,病理学特征为微小腺体增生,可伴有不典型增生,并见细胞实性增生及印戒样细胞,伴较多炎细胞浸润。该病变临床易误诊为宫颈癌,需提高对该病的认识,并结合病理组织形态学特征和免疫组化标记明确诊断。Objective:To investigate the clinical pathological features,diagnosis and differential diagnosis of cervical microglandular hyperplasia,and improve clinical awareness of the disease.Methods:The clinical data,imaging findings,pathological histological characteristics,immunohistochemical labeling signature and prognosis of two patients with cervical microglandular hyperplasia were retrospectively analyzed,and the relevant literature was reviewed.Results:Cervical microglandular hyperplasia is rare in clinic.It often presents as a polypoid neoorganism.Pathological features are hyperplasia of tiny glands,which can be accompanied by dysplasia,and solid cell hyperplasia and signet ring cells,with more inflammatory cell infiltration.Combined with the characteristics of pathological histomorphology and immunohistochemical markers,the diagnosis and differential diagnosis can be clarified.This paper reported that none of the two patients had a history of oral contraceptives,and menstrual performance was normal.All patients presented cervical polyp.The imaging examination is difficult to distinguish from cervical cancer.Immunohistochemistry showed CK,CK7,CK8,CK5/6 and VIM were expressed,but not p16,p63,p40 and CEA.p53 was wild-type,and expression of Ki-67 was low.Conclusion:Cervical microglandular hyperplasia is a rare benign space-occupying lesion.Pathological features are hyperplasia of tiny glands,which can be accompanied by dysplasia,and solid cell hyperplasia and signet ring cells,with more inflammatory cell infiltration.This lesion is easily misdiagnosed as cervical cancer.Increased awareness of the disease is needed,and the diagnosis needs to be clarified by pathological histomorphological characteristics and immunohistochemical markers.

关 键 词：微腺体增生 免疫组化 临床病理 诊断 鉴别诊断 

分 类 号：R737.33[医药卫生—肿瘤]