口腔幽门螺杆菌感染对慢性牙周炎患者龈沟液中炎症因子及米诺环素治疗效果的影响  

Effect of Oral Helicobacter Pylori Infection on Inflammatory Factors in Gingival Crevicular Fluid and Minocycline Treatment in Patients with Chronic Periodontitis

作　　者：张小燕 Zhang Xiaoyan(Department of Stomatology,Xinyang People’s Hospital,Xinyang,Henan,464000,China)

机构地区：[1]信阳市人民医院口腔科,河南信阳464000

出　　处：《黑龙江医学》2024年第14期1683-1686,共4页Heilongjiang Medical Journal

摘　　要：目的:分析口腔幽门螺杆菌感染(Hp)对慢性牙周炎患者龈沟液中炎症因子及米诺环素治疗效果的影响。方法:研究采用前瞻性队列研究,选取2019年4月—2022年4月信阳市人民医院口腔科收治的90例慢性牙周炎患者作为研究对象。所有患者均于治疗前进行Hp检测,依据感染情况分为感染组与未感染组,每组各45例,均接受米诺环素治疗4周。由研究者设计基线资料调查表,收集患者基线资料进行对比,分析两组患者治疗前龈沟液肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)的表达情况,并统计两组患者治疗4周后的临床效果,采用logistic回归分析Hp感染对慢性牙周炎患者米诺环素治疗效果的影响。结果:感染组龈沟液TNF-α、IL-6、IL-8水平明显高于未感染组,差异有统计学意义(t=32.221、9.742、5.533,P<0.05);应用米诺环素治疗30 d后,感染组治疗有效率低于未感染组,差异有统计学意义(χ^(2)=7.200,P<0.05);治疗无效组龈沟液TNF-α、IL-6、IL-8水平、Hp感染情况高于治疗有效组,差异有统计学意义(t=5.009、4.481、4.051,χ^(2)=7.200;P<0.05);logistic回归分析结果显示,龈沟液TNF-α、IL-6、IL-8水平高表达及Hp感染是慢性牙周炎患者治疗有效的危险因素(OR=1.003、4.137、3.487、11.000,P<0.05)。结论:慢性牙周炎患者Hp感染后龈沟液中TNF-α、IL-6、IL-8水平会明显升高,且会降低米诺环素治疗效果。Objective:To analyze the effect of oral helicobacter pylori infection(Hp)on inflammatory factors in gingival crevicular fluid(GCF)and minocycline treatment in patients with chronic periodontitis.Methods:A prospective cohort study was conducted to select 90 patients with chronic periodontitis who were admitted to Department of Stomatology of Xinyang People’s Hospital from April 2019 to April 2022.All patients were tested for Hp before treatment,and were divided into infected group and uninfected group according to the infection condition,with 45 patients in each group.All patients received minocycline treatment for 4 weeks.The baseline data questionnaire was designed and the baseline data of patients were collected for comparison.The expressions of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in gingival creval fluid of the two groups were analyzed before treatment,and the clinical effects of the two groups were statistically analyzed after 4 weeks of treatment.Analytical logistic regression was used to analyze the effect of Hp infection on the treatment of minocycline in patients with chronic periodontitis.Results:The levels of TNF-α,IL-6 and IL-8 in gingival crevicular fluid in the infected group were significantly higher than those in the uninfected group before treatment,with statistically significant difference(t=32.221,9.742,5.533;P<0.05).After 30 days of minocycline treatment,the effective rate of the infected group was lower than that of the uninfected group,with statistically significant difference(χ^(2)=7.200,P<0.05).The levels of TNF-α,IL-6,IL-8 in gingival creval fluid and Hp infection in the ineffective treatment group were higher than those in the effective treatment group,and the differences were statistically significant(t=5.009,4.481,4.051;χ^(2)=7.200;P<0.05).Logistic regression analysis showed that high expression of TNF-α,IL-6,IL-8 in gingival crevicular fluid and Hp infection were risk factors for effective treatment of chronic periodontitis(OR=1.003,4.137,3

关 键 词：慢性牙周炎 口腔幽门螺杆菌 龈沟液 肿瘤坏死因子-α 白细胞介素 治疗效果 

分 类 号：R781.42[医药卫生—口腔医学]