雌二醇/总睾酮预测子宫内膜息肉患者宫腔镜术后复发研究  

Estradiol/Testosterone Prediction of Postoperative Recurrence in Patients with Endometrial Polyps Undergoing Hysteroscopy

作　　者：李秋辉 蔡晓环 郑晓惠 Li Qiuhui;Cai Xiaohuan;Zheng Xiaohui(Department of Gynecology,Xinyang People’s Hospital,Xinyang,Henan,464101,China)

机构地区：[1]信阳市人民医院妇科,河南信阳464101

出　　处：《黑龙江医学》2024年第14期1710-1713,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨雌二醇(E_(2))/总睾酮(T)对子宫内膜息肉患者宫腔镜术后复发的预测价值,为临床预防复发提供理论参考。方法:采用前瞻性研究,选取2020年1月—2022年1月信阳市人民医院择期实施宫腔镜子宫内膜息肉切除术治疗的153例子宫内膜息肉患者作为研究对象。在术后第1个月经周期的第7 d检测患者的E_(2)、T,计算E_(2)/T水平,统计相关指标。予以14个月随访,根据随访期间疾病是否复发将患者分为复发组与未复发组,比较两组患者基线资料,采用logistic回归分析检验影响子宫内膜息肉患者宫腔镜术后复发的影响因素,并绘制受试者工作曲线(ROC)分析E_(2)/T对子宫内膜息肉患者宫腔镜术后复发的预测价值。结果:153例患者中有40例复发,复发率为26.14%。复发组与未复发组患者在E_(2)、T、E_(2)/T、雌激素受体(ER)、环氧合酶-2(COX-2)方面比较,差异有统计学意义(t=6.111、2.061、7.399;χ^(2)=5.239、5.687,P<0.05)。logistic回归分析发现,E_(2)、T、E_(2)/T、ER是影响子宫内膜息肉患者术后复发的相关因素(P<0.05)。绘制ROC发现E_(2)、E_(2)/T对术后复发具有中等的预测价值,曲线下面积(AUC)分别为0.784、0.806,T对患者术后复发预测价值较低,AUC为0.608。结论:E_(2)/T可以作为预测子宫内膜息肉患者术后复发的临床指标。Objective:To explore the predictive value of estradiol(E_(2))/total testosterone(T)for postoperative recurrence of endometrial polyps in patients undergoing hysteroscopy,and to provide theoretical reference for clinical prevention of recurrence.Methods:A prospective study was conducted,and 153 patients with endometrial polyps who underwent hysteroscopic endometrial polypectomy in Xinyang People’s Hospital from January 2020 to January 2022 were selected as the study subjects.On the 7th day of the first menstrual cycle after surgery,the patient’s E_(2) and T levels were measured,E_(2)/T levels were calculated,relevant indicators were statistically analyzed.14 month follow-up was conducted.The patient was divided into a recurrent group and a non recurrent group based on whether the disease recurred during the follow-up period.The baseline data of the two groups were compared.Logistic regression analysis was used to test the influencing factors of recurrence after hysteroscopy in patients with endometrial polyps,and the receiver operating curve(ROC)was drawn to analyze the predictive value of E_(2)/T for recurrence after hysteroscopy in patients with endometrial polyps.Results:Among 153 patients,40 had recurrence,with a recurrence rate of 26.14%.There was statistical significant difference in E_(2),T,E_(2)/T,estrogen receptor(ER),cyclooxygenase-2(COX-2)between the recurrent group and the non recurrent group(t=6.111,2.061,7.399;χ^(2)=5.239,5.687;P<0.05).Logistic regression analysis showed that E_(2),T,E_(2)/T and ER were the relevant factors affecting postoperative recurrence in patients with endometrial polyps(P<0.05).ROC analysis showed that E_(2) and E_(2)/T had moderate predictive value for postoperative recurrence,with area under the curve(AUC)of 0.784 and 0.806,respectively.T had a low predictive value for postoperative recurrence,with AUC of 0.608.Conclusion:E_(2)/T can be used as a clinical indicator to predict postoperative recurrence in patients with endometrial polyps.

关 键 词：雌二醇 总睾酮 子宫内膜息肉 腹腔镜子宫内膜息肉切除术 复发 预测 

分 类 号：R730.269[医药卫生—肿瘤]