吸烟对非小细胞肺癌患者ERCC1和RRM1表达的影响及与预后的相关性  

Effect of Smoking on Expression of ERCC1 and RRM1 in Patients with Non-small Cell Lung Cancer

作　　者：宋开放 刘谷一 孙江涛[1] SONG Kaifang;LIU Guyi;SUN Jiangtao(Surgery of Lung Cancer,the First Affiliated Hospital of Henan University of Science and Technology College,Luoyang 471003,China)

机构地区：[1]河南科技大学第一附属医院肺肿瘤外科,河南洛阳471003

出　　处：《河南医学研究》2024年第13期2347-2350,共4页Henan Medical Research

基　　金：河南省重点研发与推广专项支持项目(222102310339)。

摘　　要：目的探讨吸烟对非小细胞肺癌(NSCLC)患者切除修复交叉互补基因1(ERCC1)和核糖核苷酸还原酶M1(RRM1)表达的影响及其与预后的关系。方法收集2015年8月至2018年8月河南科技大学第一附属医院收治的131例ⅢB期、Ⅳ期的NSCLC患者。依据有无吸烟史将患者分为两组,其中非吸烟组64例,吸烟组67例,检测各组ERCC1和RRM1的表达水平,分析其与患者临床资料的相关性以及对患者预后的影响。结果吸烟组ERCC1高表达患者占比多于非吸烟组(P<0.05);两组ERCC1和RRM1的表达水平与患者性别、年龄、肿瘤大小、病理类型无关(P>0.05);吸烟指数≥400的患者ERCC1表达较高(P=0.018);两组ERCC1和RRM1低表达的患者化疗有效率均高于高表达患者(χ^(2)=6.194,P=0.013;χ^(2)=5.012,P=0.025);与吸烟组比较,非吸烟组化疗有效率高(P=0.045),1 a复发率低(P=0.001),无进展生存期(P=0.008)和总生存期长(P=0.005)。结论吸烟影响ERCC1的表达,且吸烟指数越高的患者ERCC1表达越高;而RRM1的表达与吸烟无关。吸烟患者化疗有效率、1 a复发率低于非吸烟患者,无进展生存期及生存期均短于非吸烟患者。Objective To investigate the effect of smoking on the expression of excision repair cross complement-1(ERCC1)and ribonucleotide reductase subunit M1(RRM1)in non-small cell lung cancer(NSCLC)patients and their relationship with prognosis.Methods A total of 131 patients with stageⅢB andⅣNSCLC in the First Affiliated Hospital of Henan University of Science and Technology from August 2015 to August 2018 were collected.Patients were divided into two groups based on their smoking history,with 64 cases in the non-smoking group and 67 cases in the smoking group.The expression levels of ERCC1 and RRM1 in each group was detected,their correlation with clinical data of patients,and their impact on patient prognosis was analyzed.Results The proportion of patients with high expression of ERCC1 in the smoking group was higher than that in the non-smoking group(P<0.05).The expression levels of ERCC1 and RRM1 in two groups were not related to gender,age,tumor size and pathological type(P>0.05).Patients with a smoking index≥400 showed higher expression of ERCC1(P=0.018).The chemotherapy efficacy of two groups with low expression of ERCC1 and RRM1 was higher than that of patients with high expression(χ^(2)=6.194,P=0.013;χ^(2)=5.012,P=0.025).Compared with the smoking group,the non-smoking group had a higher chemotherapy efficacy rate(P=0.045),lower 1-year recurrence rate(P=0.001),longer progression free survival(P=0.008)and overall survival(P=0.005).Conclusion Smoking affects the expression of ERCC1,and the higher the smoking index,the higher the expression of ERCC1 in patients.The expression of RRM1 is not related to smoking.The chemotherapy response rate,1-year recurrence rate were lower than those of non-smoking patients,progression-free survival and survival were shorter than those of non-smoking patients.

关 键 词：非小细胞肺癌 切除修复交叉互补基因1 核糖核苷酸还原酶M1 吸烟 预后 

分 类 号：R734.2[医药卫生—肿瘤]