肺癌患者血清CA724、CA153、SCC水平与病理特征及术后复发转移的关系  

Relationship Between Serum CA724,CA153,SCC and Pathological Characteristics,Postoperative Recurrence and Metastasis in Patients with Lung Cancer

作　　者：卢华伟 郭庆伟[1] 毛国璋[1] LU Huawei;GUO Qingwei;MAO Guozhang(Department of General Thoracic Surgery,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]周口市中心医院普胸外科,河南周口466000

出　　处：《河南医学研究》2024年第13期2381-2385,共5页Henan Medical Research

摘　　要：目的探讨肺癌(LC)患者血清糖类抗原724(CA724)、糖类抗原153(CA153)、鳞癌抗原(SCC)水平与病理特征及术后复发转移的关系。方法选取2019年6月至2020年12月在周口市中心医院接受手术治疗的102例LC患者,根据其2 a后是否存在复发转移分为复发转移组和未复发转移组,比较两组术前血清CA724、CA153和SCC水平及病理特征,分析影响术后复发转移的因素。结果随访后,102例患者中有65例发生复发转移,发生率为63.73%;复发转移组CA724、CA153和SCC水平均高于未复发转移组(P<0.05);腺癌组CA724水平高于小细胞肺癌组和鳞癌组(P<0.05),3组CA153水平差异无统计学意义(P>0.05);鳞癌组SCC水平高于小细胞肺癌组和腺癌组(P<0.05)。Ⅱ期和Ⅲ期CA724、CA153和SCC水平高于Ⅰ期(P<0.05)。复发转移组和未复发转移组TNM分期和分化程度差异有统计学意义(P<0.05)。Cox单因素回归分析结果显示,TNM分期、高水平CA724、CA153、SCC和分化程度是LC患者术后复发转移的影响因素(P<0.05);多因素回归分析结果显示,TNM分期为Ⅲ期和高水平的CA724、CA153和SCC均为影响LC患者术后复发转移的独立危险因素(P<0.05)。结论LC患者血清CA724、CA153、SCC表达水平与LC病理特征和术后复发转移关系密切,临床可通过检测血清CA724、CA153、SCC水平来评估术后复发转移情况。Objective To explore the relationship between serum carbohydrate antigen 724(CA724),carbohydrate antigen 153(CA153),squamous cell carcinoma antigen(SCC)and pathological characteristics,postoperative recurrence and metastasis in patients with lung cancer(LC).Methods A total of 102 patients with LC undergoing surgical treatment in Zhoukou Central Hospital were enrolled from June 2019 to December 2020.According to presence or absence of recurrence and metastasis at 2 years after surgery,they were divided into recurrence-metastasis group and non-recurrence-metastasis group,the levels of serum CA724,CA153 and SCC,and pathological characteristics in the two groups were compared.The influencing factors of postoperative recurrence and metastasis were analyzed.Results After follow-up,65 out of 102 patients experienced recurrence and metastasis,accounting for 63.73%.The levels of CA724,CA153 and SCC in recurrence-metastasis group were higher than those in non-recurrence-metastasis group(P<0.05).CA724 level in adenocarcinoma group was higher than those in small cell lung cancer group and squamous cell carcinoma group(P<0.05),but there was no statistical difference in CA153 level among the three groups(P>0.05).SCC level in squamous cell carcinoma group was higher than those in small cell lung cancer group and adenocarcinoma group(P<0.05).The levels of CA724,CA153 and SCC in patients at stages Ⅱ and Ⅲ were higher than those at stage Ⅰ(P<0.05).There were statistical differences in TNM staging and differentiation degree between recurrence-metastasis group and non-recurrence-metastasis group(P<0.05).The results of Cox univariate regression analysis showed that TNM staging,high levels of CA724,CA153 and SCC,and differentiation degree were influencing factors of postoperative recurrence and metastasis in LC patients(P<0.05).The results of multivariate regression analysis showed that TNM staging at stage Ⅲ,and high levels of CA724,CA153 and SCC were independent risk factors of postoperative recurrence and metastasis.Conclus

关 键 词：糖类抗原724 糖类抗原153 鳞癌抗原 肺癌 病理 复发转移 

分 类 号：R734.2[医药卫生—肿瘤]