替格瑞洛联合盐酸替罗非班对脑卒中患者的作用效果  

Effect of Ticagrelor Combined with Tirofiban Hydrochloride on Stroke Patients

作　　者：慕同禄[1] 朱华伟[1] 牛壮 MU Tonglu;ZHU Huawei;NIU Zhuang(Department of Neurology,Puyang Anyang District Hospital,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院神经内科,河南安阳455000

出　　处：《河南医学研究》2024年第13期2426-2429,共4页Henan Medical Research

摘　　要：目的探究替格瑞洛联合盐酸替罗非班对脑卒中患者的作用效果。方法选取152例脑卒中患者被随机分为对照组和观察组,每组76例。对照组接受替格瑞洛治疗,观察组接受盐酸替罗非班联合替格瑞洛治疗。比较两组患者神经功能、血流变化、血小板参数、血小板标志物、不良反应。结果治疗后两组神经功能、国立卫生研究院卒中量表(NIHSS)评分降低,Barthel指数(BI)升高(P<0.05)。观察组的NIHSS评分低于对照组(P<0.01),BI指数高于对照组(P<0.01)。治疗后,两组CD62P、CD63阳性率和P-selectin、血小板黏附性(PADT)和血小板聚集率(PAGT)水平下降(P<0.05),且观察组均低于对照组(P<0.05)。术后3个月的随访中,观察组患者不良心血管事件的发生率低于对照组(P<0.05)。结论替格瑞洛联合盐酸替罗非班可改善脑卒中患者神经功能、提高日常生活能力、降低血小板活动性以及减少主要不良心血管事件的发生率。Objective To explore the effect of ticagrelor combined with tirofiban hydrochloride on stroke patients.Methods A total of 152 stroke patients were randomly divided into a control group and an observation group,with 76 cases in each group.The control group received treatment with ticagrelor,while the observation group received treatment with tirofiban hydrochloride combined with ticagrelor.The neurological function,blood flow changes,platelet parameters,platelet markers,and adverse reactions between two groups of patients were compared.Results After treatment,the neurological function and National Institutes of Health stroke scale(NIHSS)scores decreased in both groups,while the Barthel index(BI)increased(P<0.05).The NIHSS score of the observation group was lower than that of the control group(P<0.01),and the BI index was higher than that of the control group(P<0.01).After treatment,the positive rates of CD62P and CD63,as well as the levels of P-selectin,platelet adhesion test(PADT),and platelet aggregation test(PAGT),decreased in both groups(P<0.05),and the observation group was lower than the control group(P<0.05).During the 3-month follow-up after surgery,the incidence of adverse cardiovascular events in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of ticagrelor and tirofiban hydrochloride can improve neurological function,enhance daily living ability,reduce platelet activity,and reduce the incidence of major adverse cardiovascular events in stroke patients.

关 键 词：脑卒中 替格瑞洛 盐酸替罗非班 疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]