膈下逐瘀汤加减联合紫杉醇、顺铂新辅助化疗在宫颈癌气滞血瘀证患者中的应用效果  

Application Effect of Subphreatic Zhuyu Decoction Combined with Paclitaxel,Cisplatin Neoadjuvant Chemotherapy in Patients with Cervical Cancer Syndrome of Qi Stagnation and Blood Stasis

作　　者：钱玉红 刘凌齐 QIAN Yuhong;LIU Lingqi(Department of Oncology and Hematology,Shangqiu Traditional Chinese Medicine Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市中医院肿瘤血液科,河南商丘476000

出　　处：《河南医学研究》2024年第13期2443-2447,共5页Henan Medical Research

摘　　要：目的探讨膈下逐瘀汤加减联合紫杉醇、顺铂新辅助化疗在宫颈癌气滞血瘀证患者中的应用效果。方法选择2021年1月至2022年12月医院收治的68例宫颈癌患者,以随机数字表法分为研究组(34例)与对照组(34例)。对照组接受紫杉醇、顺铂新辅助化疗治疗,研究组在对照组基础上接受膈下逐瘀汤加减治疗。对比两组中医证候评分、临床疗效、免疫功能、肿瘤标志物及不良反应。结果治疗后,两组中医证候评分均降低,且研究组更低(P<0.05)。研究组总有效率(94.12%)比对照组(70.59%)高(P<0.05)。治疗后,研究组CD3^(+)、CD4^(+)水平均升高,对照组CD3^(+)、CD4^(+)水平均降低,研究组高于对照组(P<0.05);治疗后,研究组CD8^(+)水平降低,对照组CD8^(+)水平升高,且研究组低于对照组(P<0.05)。治疗后,两组血清鳞状上皮细胞癌抗原(SCCA)、细胞角蛋白19片段21-1(CYFRA21-1)、癌胚抗原(CEA)水平均降低,且研究组更低(P<0.05)。两组Ⅰ~Ⅳ级胃肠道反应、肝肾异常、骨髓抑制发生率差异无统计学意义(P>0.05)。结论膈下逐瘀汤加减联合紫杉醇、顺铂新辅助化疗治疗宫颈癌气滞血瘀证患者的效果确切,可改善患者免疫功能,降低肿瘤标志物水平,且安全可靠。Objective To investigate the application effect of subphreatic Zhuyu decoction combined with paclitaxel,cisplatin neoadjuvant chemotherapy in patients with cervical cancer syndrome of Qi stagnation and blood stasis.Methods A total of 68 patients with cervical cancer admitted to the hospital from January 2021 to December 2022 were selected and divided into study group(34 cases)and control group(34 cases)by random number table method.The control group received neoadjuvant chemotherapy with paclitaxel,cisplatin,and the study group received subphreatic Zhuyu decoction on the basis of the control group.TCM syndrome score,clinical efficacy,immune function,tumor markers and toxic and side effects were compared between the two groups.Results After treatment,TCM syndrome score of 2 groups was decreased,and the study group was lower(P<0.05).The total effective rate of the study group(94.12%)was higher than the control group(70.59%)(P<0.05).After treatment,the levels of CD3+and CD4+in the study group were increased,while those in the control group were decreased,and the levels of the study group were higher than the control group(P<0.05).After treatment,the level of CD8+in the study group was decreased,while that in the control group was increased,and the level of the study group was lower than the control group(P<0.05).After treatment,serum squamous cell carcinoma antigen(SCCA),cytokeratin 19 fragment 21-1(CYFRA21-1)and carcinoembryonic antigen(CEA)levels in 2 groups were decreased,and those in the study group were lower(P<0.05).There were no statistical differences in the incidence of gastrointestinal reactions,hepatorenal abnormalities and myelosuppression in classⅠtoⅣbetween the two groups(P>0.05).Conclusion In the treatment of patients with cervical cancer syndrome of Qi stagnation and blood stasis,subphreatic Zhuyu decoction combined with paclitaxel,cisplatin neoadjuvant chemotherapy is effective,which can improve the immune function of patients,reduce the level of tumor markers,and is safe and reliable.

关 键 词：膈下逐瘀汤 紫杉醇 顺铂 新辅助化疗 宫颈癌 气滞血瘀证 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]