E-钙黏蛋白表达与膀胱癌患者预后的相关性研究  

Correlation and analysis of E-cadherin expression and prognosis in patients with bladder cancer

作　　者：于湧[1] 刘智明[1] 许玲芬[2] Yu Yong;Liu Zhiming;Xu Lingfen(Department of Urology,Qinghai Province People′s Hospital,Xining 810007,China;Department of General Medicine,Qinghai Provincial People′s Hospital,Xining 810007,China)

机构地区：[1]青海省人民医院泌尿外科,西宁810007 [2]青海省人民医院全科医学科,西宁810007

出　　处：《国际泌尿系统杂志》2024年第4期641-644,共4页International Journal of Urology and Nephrology

基　　金：青海省科技计划项目(2016-ZJ-798)。

摘　　要：目的探讨E-钙黏蛋白表达与膀胱癌患者的疾病进展和生存的相关性。方法选择2016年1月至2018年1月在本院泌尿外科行膀胱活检的153例膀胱癌患者作为研究对象,收集所有患者的膀胱癌组织及距原发灶>5 cm的癌旁正常组织。对比膀胱癌组织及癌旁正常组织中的E-钙黏蛋白表达的阳性率,观察E-钙黏蛋白在初发膀胱癌和复发膀胱癌组织中的表达,采用Cox回归模型分析膀胱癌复发的危险因素。结果癌旁正常组织中的E-钙黏蛋白阳性率为90%(138/153),明显高于膀胱癌组织的阳性率[52%(80/153)],差异有统计学意义(χ^(2)=9.29,P<0.05)。初发膀胱癌和复发膀胱癌患者的E-钙黏蛋白阳性率分别为65%(65/100)、30%(16/53),差异有统计学意义(χ^(2)=15.33,P<0.05)。多因素Cox回归模型分析结果显示,E-钙黏蛋白阳性表达是膀胱癌复发的独立影响因素(P<0.05)。结论E-钙黏蛋白表达与膀胱癌患者的预后密切相关。Objective The purpose of this study was to investigate whether E-cadherin expression is related to disease progression and survival in patients with bladder cancer.Methods A total of 153 patients with bladder cancer who underwent bladder biopsy in our hospital from January 2016 to January 2018 were selected as the research objects.Bladder cancer tissues and adjacent normal tissues>5 cm away from the primary lesion of all patients were collected.The positive rate of E-cadherin expression in bladder cancer tissues and adjacent normal tissues was compared,the expression of E-cadherin in incipient and recurrent bladder cancer tissues was observed,and the risk factors of recurrent bladder cancer were analyzed by Cox regression model.Results The positive rate of E.calcin in adjacent normal tissues was 90%(138/153),which was significantly higher than that in bladder tumor tissues[52%(80/153)],and the difference was statistically significant(χ^(2)=9.29,P<0.05).The positive rates of E-cadherin in patients with primary bladder cancer and recurrent bladder cancer were 65%(65/100)and 30%(16/53),respectively,and the difference was statistically significant(χ^(2)=15.33,P<0.05).Multivariate Cox regression model analysis showed that E-cadherin positive expression was an independent factor influencing the recurrence of bladder cancer(P<0.05).Conclusions E-cadherin expression is closely related to the prognosis of patients with bladder cancer.

关 键 词：膀胱肿瘤 E-钙黏蛋白 复发 

分 类 号：R737.14[医药卫生—肿瘤]