儿童神经母细胞瘤中FAIM2的表达及临床意义  

Expression and Clinical Significance of FAIM2 in Pediatric Neuroblastoma

作　　者：刘昕晨 孙念政[1] Liu Xinchen;Sun Nianzheng(Department of Pediatric Internal Medicine,Shandong University Qilu Hospital,Jinan 250012,Shandong Province,China)

机构地区：[1]山东大学齐鲁医院小儿内科,山东济南250012

出　　处：《中外医药研究》2024年第17期6-8,F0003,共4页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探索Fas细胞凋亡抑制分子2(FAIM2)在儿童神经母细胞瘤中的表达及与其临床病理因子的关系。方法:筛选2020年1月—2022年12月就诊于山东大学齐鲁医院并经病理检查证实为神经母细胞瘤的标本33例,收集其临床资料并随访其预后情况,通过免疫组织化学法检验FAIM2蛋白在33例神经母细胞瘤组织内的表达情况,研究FAIM2的表达与神经母细胞瘤患者各项临床及病理学因子的关系,分析其对预后的影响。结果:在神经母细胞瘤组织中FAIM2蛋白的表达与肿瘤转移有相关性,其中有转移的神经母细胞瘤中FAIM2表达低于无转移病例,差异有统计学意义(P<0.05);而FAIM2的表达与肿瘤组织学类型、肿瘤大小、发病年龄、临床危险度、ki-67阳性指数、乳酸脱氢酶及神经元特异性烯醇化酶水平无明显相关。FAIM2阴性表达的神经母细胞瘤生存时间短于阳性,差异有统计学意义(P<0.05);FAIM2阴性表达和骨髓浸润是影响神经母细胞瘤患者预后的危险因素(P<0.05)。结论:FAIM2在有转移的神经母细胞瘤病例中表达水平降低,并且与患者预后密切相关,提示其可能是参与儿童神经母细胞瘤发展和转移的重要分子生理学机制。Objective:To explore the expression of fas apoptotis inhibitory molecules(FAIM2)in pediatric neuroblastoma and its relationship with clinicopathologic factors.Methods:Thirty-three samples of neuroblastoma confirmed by pathological examination were selected from Shandong University Qilu Hospital from January 2020 to December 2022.Clinical data were collected and the prognosis was followed up.The expression of FAIM2 protein in 33 neuroblastoma tissues was examined by immunohistochemistry.The relationship between FAIM2 expression and various clinical and pathological factors in neuroblastoma patients were studied,and its influence on prognosis was analyzed.Results:The expression of FAIM2 protein in neuroblastoma tissues was correlated with tumor metastasis,and FAIM2 expression in neuroblastoma with metastasis was lower than that in neuroblastoma without metastasis,the difference was statistically significant(P<0.05);FAIM2 expression had no significant correlation with tumor histological type,tumor size,age of onset,clinical risk,ki-67 positive index,lactate dehydrogenase and neuron-specific enolase levels;the survival time of neuroblastoma with FAIM2 negative expression was shorter than that with FAIM2 positive expression,and the difference was statistically significant(P<0.05);FAIM2 negative expression and bone marrow infiltration were risk factors for the prognosis of neuroblastoma patients(P<0.05).Conclusion:The expression level of FAIM2 is decreased in neuroblastoma cases with metastasis and is closely related to patient prognosis,suggesting that FAIM2 may be an important molecular physiological mechanism involved in the development and metastasis of pediatric neuroblastoma.

关 键 词：Fas细胞凋亡抑制分子2 神经母细胞瘤 肿瘤转移 预后 

分 类 号：R730.2[医药卫生—肿瘤]