普萘洛尔联合常规药物治疗肝硬化食管胃底静脉曲张破裂出血术后患者的效果  

Effects of Propranolol combined with conventional drugs in treatment of postoperative patients with liver cirrhosis and esophageal and gastric variceal bleeding

作　　者：刘路 段才华 夏国盛 朱晨 LIU Lu;DUAN Caihua;XIA Guosheng;ZHU Chen(Department of Gastroenterology of Ji’an Central People’s Hospital,Ji’an 343000 Jiangxi,China)

机构地区：[1]吉安市中心人民医院消化内科,江西吉安343000

出　　处：《中国民康医学》2024年第14期34-36,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察普萘洛尔联合常规药物治疗肝硬化食管胃底静脉曲张破裂出血术后患者的效果。方法:选取2020年1月至2023年1月于该院行内镜下套扎术的84例肝硬化食管胃底静脉曲张破裂出血患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各42例。对照组术后予以常规药物(生长抑素+奥美拉唑)治疗,研究组在对照组基础上联合普萘洛尔治疗。比较两组临床疗效,治疗前后门静脉指标(门静脉血流速度、门静脉血流量)水平,不良反应发生率,以及食管胃底静脉曲张再出血率。结果:研究组治疗总有效率为95.24%(40/42),高于对照组的78.57%(33/42),差异有统计学意义(P<0.05);治疗后,两组门静脉血流速度、门静脉血流量均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);研究组食管胃底静脉曲张再出血率为2.38%(1/42),低于对照组的19.05%(8/42),差异有统计学意义(P<0.05)。结论:普萘洛尔联合常规药物治疗肝硬化食管胃底静脉曲张破裂出血术后患者可提高治疗总有效率,改善门静脉指标水平,降低再出血率,效果优于单纯常规药物治疗。Objective:To observe effects of Propranolol combined with conventional drugs in treatment of postoperative patients with liver cirrhosis and esophageal and gastric variceal bleeding.Methods:From January 2020 to January 2023,84 patients with liver cirrhosis and esophageal and gastric variceal bleeding who underwent endoscopic variceal ligation in the hospital were selected for the prospective study.According to the random number table method,they were divided into study group and control group,42 cases in each group.The control group was treated with conventional drugs(Somatostatin+Omeprazole)after the surgery,while the study group was treated with Propranolol on the basis of that of the control group.The clinical efficacy,the portal vein index(portal vein blood flow velocity,portal vein blood flow)levels before and after the treatment,the incidence of adverse reactions,and the rebleeding rate of esophageal and gastric varices were compared between the two groups.Results:The total effective rate of the study group was 95.24%(40/42),which was higher than 78.57%(33/42)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of portal vein blood flow velocity and portal vein blood flow in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The rebleeding rate of esophageal and gastric varices in the study group was 2.38%(1/42),which was lower than 19.05%(8/42)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Propranolol combined with conventional drugs can improve the total effective rate of treatment,improve the levels of portal vein indexes and reduce the rebleeding rate in the postoperative patients with liver cirrhosis and esophageal and gastric variceal bleeding.Moreover,it is super

关 键 词：肝硬化 食管胃底静脉曲张破裂出血 术后 普萘洛尔 生长抑素 奥美拉唑 再出血 

分 类 号：R573.2[医药卫生—消化系统]