帕罗西汀与氟西汀治疗中青年广泛性焦虑障碍患者的效果比较  

Comparison of effects of Paroxetine and Fluoxetine in treatment of young and middleaged patients with generalized anxiety disorder

作　　者：刘瑞瑞 Liu Ruirui(Department of Clinical Psychology of the Sixth People’s Hospital of Puyang,Puyang 457000 Henan,China)

机构地区：[1]濮阳市第六人民医院临床心理科,河南濮阳457000

出　　处：《中国民康医学》2024年第14期76-79,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较帕罗西汀与氟西汀治疗中青年广泛性焦虑障碍患者的效果。方法:选取2022年2月至2023年2月该院收治的70例中青年广泛性焦虑障碍患者进行前瞻性研究,以随机数字表法将其分为对照组和研究组各35例。对照组采用氟西汀治疗,研究组采用帕罗西汀治疗,比较两组临床疗效,治疗前及治疗1、3个月后焦虑[汉密尔顿焦虑量表(HAMA)]、睡眠质量[匹兹堡睡眠质量指数(PSQI)]评分,以及治疗前后血清细胞因子[谷胱甘肽过氧化物酶(GSH-Px)、5-羟色胺(5-HT)、超氧化物歧化酶(SOD)]水平。结果:研究组治疗总有效率为100.00%(35/35),高于对照组的82.86%(29/35),差异有统计学意义(P<0.05);治疗1、3个月后,研究组HAMA和PSQI评分均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组GSH-Px、5-HT、SOD水平均高于对照组,差异有统计学意义(P<0.05)。结论:帕罗西汀治疗中青年广泛性焦虑障碍患者可提高治疗总有效率和血清细胞因子水平,降低HAMA和PSQI评分,效果优于氟西汀治疗。Objective:To compare effects of Paroxetine and Fluoxetine in treatment of young and middle-aged patients with generalized anxiety disorder.Methods:A prospective study was conducted on 70 young and middle-aged patients with generalized anxiety disorder admitted to this hospital from February 2022 to February 2023.They were divided into control group and study group by using the random number table method,35 cases in each group.The control group was treated with Fluoxetine,while the study group was treated with Paroxetine.The clinical efficacy,the anxiety[Hamilton anxiety scale(HAMA)]and the sleep quality[Pittsburgh sleep quality index(PSQI)]scores before and 1 and 3 months after the treatment,and the serum cytokine indexes[glutathione peroxidase(GSH-Px),5-hydroxytryptamine(5-HT),superoxide dismutase(SOD)]levels before and after the treatment were compared between the two groups.Results:The total effective rate of treatment in the study group was 100.00%(35/35),which was higher than 82.86%(29/35)in the control group,and the difference was statistically significant(P<0.05).After 1 and 3 months of treatment,the scores of HAMA and PSQI in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the levels of GSH-Px,5-HT and SOD in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Paroxetine in the treatment of the young and middle-aged patients with generalized anxiety disorder can improve the total effective rate of treatment and the serum cytokine levels,and reduce the HAMA and PSQI scores.Moreover,it is superior to Fluoxetine treatment.

关 键 词：中青年 广泛性焦虑障碍 氟西汀 帕罗西汀 细胞因子 睡眠质量 

分 类 号：R749[医药卫生—神经病学与精神病学]