血清Bcl-2、IGF-1、CA19-9水平联合检测对食管癌的诊断价值  

Diagnostic value of combined detection of serum Bcl-2,IGF-1 and CA19-9 levels in esophageal cancer

作　　者：朱银峰 史豫家 ZHU Yinfeng;SHI Yujia(Department of Clinical Laboratory of the Third People’s Hospital of Shangqiu,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第三人民医院检验科,河南商丘476000

出　　处：《中国民康医学》2024年第14期131-133,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清B细胞淋巴瘤-2(Bcl-2)、胰岛素样生长因子-1(IGF-1)、糖类抗原19-9(CA19-9)水平联合检测对食管癌的诊断价值。方法:回顾性分析2020年1月至2023年8月该院收治的126例疑似食管癌患者的临床资料。所有患者均接受血清学检测和内镜下病理活检,比较良恶性患者及不同病理特征食管癌患者的血清Bcl-2、IGF-1、CA19-9水平。采用受试者工作特征(ROC)曲线分析血清Bcl-2、IGF-1、CA19-9水平单项及联合检测对食管癌的诊断价值。结果:126例疑似食管癌患者中,病理学检出恶性肿瘤(食管癌)70例,其中鳞癌54例,腺癌16例;良性病变56例,其中不典型增生37例,平滑肌瘤19例。恶性患者血清Bcl-2、IGF-1、CA19-9水平均高于良性患者,高分期、低分化、有淋巴结转移的食管癌患者血清Bcl-2、IGF-1、CA19-9水平高于低分期、中高分化、无淋巴结转移的患者,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,血清Bcl-2、IGF-1、CA19-9水平单项及联合检测诊断食管癌的曲线下面积分别为0.802、0.836、0.767、0.918,联合检测的诊断价值高于单一指标检测。结论:血清Bcl-2、IGF-1、CA19-9水平联合检测诊断食管癌的价值高于单一指标检测。Objective:To analyze diagnostic value of combined detection of serum B-cell lymphoma-2(Bcl-2),insulin-like growth factor-1(IGF-1)and carbohydrate antigen 19-9(CA19-9)levels in esophageal cancer.Methods:The clinical data of 126 patients with suspected esophageal cancer admitted to this hospital from January 2020 to August 2023 were retrospectively analyzed.All patients underwent serological tests and endoscopic biopsy.The levels of serum Bcl-2,IGF-1 and CA19-9 were compared among the patients with benign and malignant tumors and among the malignant patients with different pathological characteristics.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of single and combined detection of serum Bcl-2,IGF-1 and CA19-9 levels for esophageal cancer.Results:In the 126 patients with suspected esophageal cancer,70 cases of malignant tumors were detected by pathology,including 54 cases of squamous cell carcinoma and 16 cases of adenocarcinoma.There were 56 benign cases,including 37 cases of atypical hyperplasia and 19 cases of leiomyoma.The levels of serum Bcl-2,IGF-1 and CA19-9 in the malignant patients were higher than those in the benign patients;the serum levels of Bcl-2,IGF-1 and CA19-9 in the patients with high stage,low differentiation and lymph node metastasis were higher than those in the patients with low stage,middle and high differentiation and no lymph node metastasis;and the differences were statistically significant(P<0.05).ROC curve showed that the areas under the curve of single and combined detection of serum Bcl-2,IGF-1 and CA19-9 levels in the diagnosis of esophageal cancer was 0.802,0.836,0.767 and 0.918,separately.The diagnostic value of combined detection was higher than that of single index detection.Conclusions:The value of combined detection of serum Bcl-2,IGF-1 and CA19-9 levels in the diagnosis of esophageal cancer is higher than that of single index detection.

关 键 词：食管癌 B淋巴细胞瘤-2 胰岛素样生长因子-1 糖类抗原19-9 诊断价值 

分 类 号：R735.1[医药卫生—肿瘤]