蒙药治疗肝纤维化机制的研究进展  

Research Progress of Mechanism of Mongolian Medicine in Treating Liver Fibrosis

作　　者：薛润国 李志群 韩志强[3] XUE Runguo;LI Zhiqun;HAN Zhiqiang(School of Medicine,Inner Mongolia Minzu University,Tongliao 028000,China;Department of Hepatobiliary,the 984th Hospital of the Joint Logistics Support Force of the Chinese PLA,Beijing 100094,China;Institute of Mongolian Pharmacology,Affiliated Hospital of Inner Mongolia Minzu University,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学临床医学院,内蒙古通辽028000 [2]联勤保障部队第九八四医院肝胆科,北京100094 [3]内蒙古民族大学附属医院蒙药药理研究所,内蒙古通辽028000

出　　处：《医学综述》2024年第16期1921-1926,共6页Medical Recapitulate

基　　金：国家自然科学基金(81860891);内蒙古自治区中医药(蒙医药)中青年领军人才培育项目(2022-〔RC005〕)。

摘　　要：肝纤维化是由肝炎和其他病因引起的一种肝脏结构和功能异常的病理变化,严重时会导致肝硬化和死亡。目前,以西医为主要治疗方式,但长期服用药物可能产生耐药性。蒙药作为传统医学的组成部分之一,被广泛应用于肝纤维化的治疗。近年来,蒙药通过多种机制治疗肝纤维化并取得一定进展,如星状细胞活化、细胞外基质沉积、基质金属蛋白酶/金属蛋白酶组织抑制物系统失衡、程序性细胞死亡、细胞自噬、信号通路调节。深入探讨蒙药治疗肝纤维化的作用机制,可为蒙药在肝纤维化治疗领域的应用和发展提供参考。Liver fibrosis is a pathological change in liver structure and function caused by hepatitis and other etiologies,which can lead to cirrhosis and death in severe cases.At present,western medicine is the main treatment method,but long-term use of drugs may lead to drug resistance.Mongolian medicine,as one of the components of traditional medicine,is widely used in the treatment of liver fibrosis.In recent years,Mongolian medicine has made certain progress in treating liver fibrosis through various mechanisms,such as activation of stellate cells,deposition of extracellular matrix,imbalance of matrix metalloproteinase/tissue inhibitor system,programmed cell death,autophagy,and regulation of signaling pathways.In-depth exploration of the mechanism of action of Mongolian medicine in treating liver fibrosis can be provided for the application and development of Mongolian medicine in the field of liver fibrosis treatment.

关 键 词：肝纤维化 蒙药 治疗机制 

分 类 号：R575.2[医药卫生—消化系统]