子宫自然杀伤细胞在复发性流产中的研究进展  

Research Progress of Uterine Natural Killer Cells in Recurrent Spontaneous Abortion

作　　者：谢娱新 储继军[1] 陈梦娜 王瑞雪[1] XIE Yuxin;CHU Jijun;CHEN Mengna;WANG Ruixue(Reproductive Center,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学第一附属医院生殖中心,合肥230031

出　　处：《医学综述》2024年第16期1931-1936,共6页Medical Recapitulate

基　　金：安徽省高等学校科学研究项目(2023AH050853)。

摘　　要：复发性流产(RSA)是一种早期妊娠并发症,其病因复杂,包括遗传、内分泌、解剖异常、感染和免疫等因素。其中,T淋巴细胞、树突状细胞和自然杀伤细胞(NK细胞)等免疫因子在RSA发生发展中的作用受到广泛关注,尤其是NK细胞,是人体免疫系统的重要组成部分。子宫NK细胞(uNK细胞)是着床时子宫内膜中数量最多的免疫细胞,在妊娠早期蜕膜血管生成、滋养层侵袭和胎盘螺旋动脉重塑中发挥重要作用。随着研究的进展,了解uNK细胞的起源、分类、功能及与RSA的关系可能为RSA的治疗和预防提供靶点。Recurrent spontaneous abortion(RSA)is an early pregnancy complication.Its etiology is complex,involving genetic factors,endocrine factors,anatomical abnormalities,infectious factors,and immune factors etc.Among these,the roles of immune factors such as T lymphocytes,dendritic cells,and natural killer cells(NK cells)in the occurrence and development of RSA have been widely concerned,particularly the NK cells.NK cells are integral components of the human immune system.Uterine NK cells(uNK cells)are the most abundant immune cells in the endometrium during implantation,which play crucial roles in decidual vascularization,trophoblast invasion,and remodeling of placental spiral arteries during early pregnancy.With advancements in the research,understanding the origin,classification,function,and association with RSA of uNK cells may provide potential targets for the treatment and prevention of RSA.

关 键 词：复发性流产 子宫自然杀伤细胞 免疫耐受 子宫动脉重塑 

分 类 号：R733[医药卫生—肿瘤]