角膜移植排斥反应中调节性T细胞的发展及应用  

Development and application of regulatory T cells in corneal transplant rejection

作　　者：杜鑫 关瑞娟[2] 亢泽峰[3] 李凌[2] 晏鑫 张晓英[2] Du Xin;Guan Ruijuan;Kang Zefeng;Li Ling;Yan Xin;Zhang Xiaoying(School of Medicine,Qinghai University,Xining 810000,Qinghai Province,China;Department of Ophthalmology,Qinghai Provincial People's Hospital,Xining 810007,Qinghai Province,China;Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]青海大学医学院,青海省西宁市810000 [2]青海省人民医院眼科,青海省西宁市810007 [3]中国中医科学院眼科医院,北京市100040

出　　处：《国际眼科杂志》2024年第8期1246-1249,共4页International Eye Science

基　　金：青海省卫健委重点课题(No.2020-WJZD-02);青海省昆仑人才·高端创新拔尖人才[No.(2021)13]

摘　　要：角膜移植术是角膜盲的有效治疗方式,是角膜盲患者复明的唯一希望。角膜无血管、无淋巴管,被称为免疫赦免器官,因此角膜移植术的成功率明显高于其他器官移植术,但角膜移植术后的排斥反应仍然是角膜移植术失败的主要原因。器官移植术后的免疫反应主要是免疫细胞向淋巴组织、炎症部位的定向移动,而调节性T细胞(regulatory T cells,Treg)在免疫调节中起着关键性作用,其可以通过调节和抑制效应T细胞的活化来诱导免疫耐受,从而减轻角膜移植术后的排斥反应。据此,文章对在角膜移植术后发生免疫排斥反应中Treg的来源、作用机制以及治疗等多方面做简单综述,同时也探讨了应用冬虫夏草提取物FTY720增强Treg的有效性,以期为后续针对性开展临床应用转化及基础研究提供一定的参考。Corneal transplantation is an effective treatment for corneal blindness,and it is the only hope for patients with corneal blindness.Cornea has no blood vessels and no lymphatic vessels,which is called immune privilege organ,so the success rate of corneal transplantation is significantly higher than that of other organ transplantation,but the rejection reaction after corneal transplantation is still the main reason for the failure of corneal transplantation.The directional movement of immune cells to lymphoid tissue and inflammatory sites is the mainly immune response after organ transplantation.And the regulatory T cells(Treg)play a key role in immune regulation,which can induce immune tolerance by regulating and inhibiting the activation of effector T cells and reduce the rejection reaction after corneal transplantation.In addition,this review also discussed the effectiveness of applying cordyceps sinensis extract FTY720 to enhance the function of Treg.Based on this,we briefly reviewed the sources,mechanism of action and treatment of Treg after corneal transplantation,so as to provide some reference for the subsequent clinical application transformation and basic research.

关 键 词：角膜移植术 排斥反应 免疫调节 调节性T细胞 

分 类 号：R779.65[医药卫生—眼科]