加味理中汤联合背俞穴位埋线治疗非酒精性脂肪性肝炎的疗效观察  

Therapeutic efficacy observation on the treatment of non-alcoholic steatohepatitis with Jiawei Lizhong Tang combined with dorsal yu acupoint burrowing

作　　者：孙东琪 吴腾 王月明 磨奕玲 刘琳 孙素红 李泽鹏 阮博文 余静芳 周晓玲 钟镇康 SUN Dong-qi;WU Teng;WANG Yue-ming;ZHOU Xiao-ling(Liuzhou Hospital of Traditional Chinese Medicine,Liuzhou Guangxi,545001,China;不详)

机构地区：[1]柳州市中医医院消化科,广西柳州545001 [2]广西中医药大学研究生院

出　　处：《中西医结合肝病杂志》2024年第7期582-586,591,共6页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：广西中医药管理局科技项目(No.GZSY20-60);广西自然科学基金青年基金(No.2020GXNSFBA297133);广西中医药大学自然科学青年基金(No.2020QN020);广西岐黄学者培养项目。

摘　　要：目的:观察加味理中汤联合背俞穴位埋线对非酒精性脂肪性肝炎(NASH)患者的临床疗效。方法:选择2020年1月至2022年12月在柳州市中医院消化科就诊的118例NASH患者为研究对象,按照随机数字表法分为对照组和观察组,每组59例。对照组患者采用西药(复方甘草酸苷胶囊),观察组患者采用中药联合埋线(加味理中汤联合背俞穴位埋线),疗程12周。检测人体学指标体重、腰围、身体质量指数(BMI);观察治疗前后肝功能指标丙氨酸氨基转移酶(ALT)、门冬氨基酸转移酶(AST)、谷氨酰胺转肽酶(GGT)、总胆红素(TBil)、血脂指标三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血糖指标空腹血糖(FBG)、空腹胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)、肝脏硬度值(LSM)、受控衰减参数值(CAP)、和肝/脾CT比值等变化,治疗结束后评定临床疗效。结果:治疗12周后,与治疗前比较,两组患者体重、腰围、BMI、血清ALT、AST、GGT、TBil及TG、TC、LDL-C、HDL-C、空腹血糖、空腹胰岛素及胰岛素抵抗指数、LSM、CAP、肝/脾CT比值均有所改善(P<0.05),且治疗后观察组上述指标改善情况均明显优于对照组(P<0.05)。结论:加味理中汤联合背俞穴位埋线治疗非酒精性脂肪性肝炎可有效改善患者病情,减轻肝功能损伤,调节血脂、胰岛素抵抗及肝脏脂肪变性,效果优于西药组。Objective:To observe the clinical efficacy of Jiawei Lizhong Tang combined with dorsal yu acupoint embedding on patients with non-alcoholic steatohepatitis.Methods:A total of 118 NASH patients attending Liuzhou Hospital of Traditional Chinese Medicine from January 2020 to December 2022 was selected for the study.They were divided into a control group and an observation group according to a simple randomized numerical table,with 59 cases in each group.The control group was treated with the compound glycyrrhizin capsule,and the observation group was treated with Jiawei Lizhong Tang combined with dorsal yu acupoint embedding,with a course of 12 weeks.Anthropological indicators of body weight,waist circumference,body mass index(BMI),liver function indicators of alanine aminotransferase(ALT),menthyl amino acid transferase(AST),glutamine transpeptidase(GGT),total bilirubin(TBil),lipid indicators of triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),total lipoprotein cholesterol(LDL-C),total lipoprotein cholesterol(LDL-C),total lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),glycemic indexes of fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR),liver stiffness(LSM),controlled attenuation parameter(CAP),liver/spleen CT ratio,etc.,and the clinical efficacy were evaluated at the end of treatment.Results:After 12 weeks of treatment,compared with the pre-treatment period,the weight,waist circumference,BMI,serum ALT,AST,GGT,TBil and TG,TC,LDL-C,HDL-C,fasting glucose,fasting insulin and insulin resistance index,LSM,CAP,and the liver/spleen CT ratio of patients in the two groups were all improved(P<0.05).The improvement of the above indexes in the observation group was significantly better than that in the control group after treatment(P<0.05).Conclusion:The treatment of non-alcoholic steatohepatitis with Jiawei Lizhong Tang combined with dorsal acupoint burrowing can effectively improve the c

关 键 词：加味理中汤 穴位埋线 非酒精性脂肪性肝炎 临床疗效 

分 类 号：R575[医药卫生—消化系统]