Initial host-pathogen interactions explained by the Organism Prearranged Recognition Theory: fundamental role of saccharides  

作　　者：Luz P.Blanco 

机构地区：[1]Systemic Autoimmunity Branch,National Institute of Arthritis and Musculoskeletal and Skin Diseases,National Institute of Health,Bethesda,USA

出　　处：《Life Research》2024年第3期9-23,共15页TMR生命研究

摘　　要：Herein based on literature available a hypothesis is provided about molecular basis for initial events in establishment interactions.This hypothesis asserts that:"recognition and interaction that occur between organisms is prearranged.There are membrane receptors with or without soluble components derived from the respective organisms that bridge specific interactions".Organisms'prearranged recognition theory(OPRT)can be specifically applied to host-microbe interactions where most microbes are coated(opsonised)by soluble components(opsonins)from the host,but there are also some microbes that can bypass host opsonization expressing receptors for the host cells or secreting host’s opsonin-like molecules.The receptors involved in organism's interactions,their specificity and repertoire depend on saccharides from glycoproteins,glycolipids,and polysaccharides(glycans)which are abundant extracellular components.Based in OPRT is possible to explain species-specific interactions and several other phenomena,such as hyper-infectivity,tissue tropism,differential sensitivity to disease depending on type O-blood,and tumoral cell promiscuity.The lipid raft domain in cellular membrane is proposed as the main location where interactions will trigger cellular responses.Possible scientific and biotechnology applications and alternative routes to modify organism's interactions and consequences are discussed.It is a novel hypothesis regarding the degree to which an organism's interactions are prearranged and the role of saccharides epitopes.

关 键 词：Species-specificity saccharides extracellular-matrix HOST-PATHOGEN ANTIBODIES 

分 类 号：R373[医药卫生—病原生物学]