Artificial Water Channel Promoting Depolymerization of Actin Filaments to Trigger Cancer Cell Apoptosis  

作　　者：Lei Zhang Yin-Gui Cao Ting Fan Jjiatong Zhao Yong-Hong Fu Qi Xiao Zhan-Ting Li Yunfeng Wang Bo Xiao Jun-Li Hou 

机构地区：[1]Department of Chemistry,Fudan University,220 Handan Road,Shanghai 200433,China [2]State Key Laboratory of Silkworm Genome Biology,Cllege of Sericulture,Textile,and Biomass Sciences Institution,Southwest University,Chongqing400715,China [3]ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital,Fudan University,Shanghai 200031 [4]Fudan International School,325 Guoquan Road,Shanghai 200433,China

出　　处：《Chinese Journal of Chemistry》2024年第12期1335-1340,共6页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(NSFC,Grant Nos.21971046,and 21921003);the Science and Technology Commission of Shanghai Municipality(STCSM,Grant No.22JC1403700)is gratefully acknowledged.

摘　　要：Actin filaments play important physiological functions,which have become potential targets of antitumor drugs.Using chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor drugs.In this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.

关 键 词：Artificial water channel Actin depolymerization Cell apoptosis NANOSTRUCTURES Molecular recognition Supramolecular chemistry 

分 类 号：R730[医药卫生—肿瘤]