Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent-Free Conditions  

作　　者：Wanqing Zuo Zhizhen Zhu Yu Cheng Lingling Zuo Xiao Geng Zhifang Li Lei Wang 

机构地区：[1]College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministryof Education,HangzhouNormal University,Hangzhou,Zhejiang311121,China [2]Advanced Research Institute and School of Pharmaceutical Sciences,Taizhou University,Jiaojiang,Zhejiang 318000,China [3]state Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai200032,China

出　　处：《Chinese Journal of Chemistry》2024年第12期1394-1398,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(22071171);the Natural Science Foundation of Zhejiang Province(LZ22B020003)for financial support of this work.

摘　　要：Comprehensive Summary The development of switchable solvent-free multicomponent reactions to build high-value-added products is an important demand for organic synthesis.Herein,we detailed the successful implementation of a switchable strategy for the construction of diverse 4-fluoroalkyl-1,4-dihydropyrimidines and 4-fluoroalkyl-pyrimidines via a solvent/additive-free[3+2+1]annulation,starting from readily available enamines,trifluoroacetaldehyde hydrate or 1-ethoxy-2,2-difluoroethanol and amidines hydrochloride.This reaction conforms to the concept of green synthesis,and provides a new avenue to access valuable fluorinated heterocycles.

关 键 词：Fluorine chemistry Multicomponent reactions Environmental chemistry HETEROCYCLES ENAMINONES AMIDINES 

分 类 号：O62[理学—有机化学]