^(18)F-AlF-NOTATATE的自动化标记方法优化及PET/CT显像研究  

Optimization of automated labeling method for ^(18)F-AlF-NOTATATE and PET/CT imaging

作　　者：张雨[1] 陈礼平[1] 贺慧慧 付海田 李庆波 王艳娟 金春阳 郁春景[1] Zhang Yu;Chen Liping;He Huihui;Fu Haitian;Li Qingbo;Wang Yanjuan;Jin Chunyang;Yu Chunjing(Department of Nuclear Medicine,Affiliated Hospital of Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学附属医院核医学科,无锡214122

出　　处：《中华核医学与分子影像杂志》2024年第7期417-421,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：江南大学附属医院临床研究与转化项目(LCYJ202203)。

摘　　要：目的研究自动化合成^(18)F-AlF-1,4,7-三氮杂环壬烷-1,4,7-三乙酸-D-苯丙胺酸1-酪氨酸3-苏氨酸8-奥曲肽(^(18)F-AlF-NOTATATE)的标记方法并进行神经内分泌肿瘤(NET)显像。方法基于GE-FASTLab2合成模块,通过氟化铝一步螯合标记的方法自动化制备^(18)F-AlF-NOTATATE,优化其标记条件,并对产品进行质量分析。对1例直肠下段NET患者(男,47岁)和1例胰腺NET患者(女,52岁)行^(18)F-AlF-NOTATATE PET/CT显像。结果成功制备了^(18)F-AlF-NOTATATE,总合成时间为35 min,优化后的放射化学产率为(23.8±3.1)%(未衰变校正,n=3),放射性活度为(4.63±0.68)GBq,放化纯>95%,稳定性好,产品质量均符合规定。^(18)F-AlF-NOTATATE在患者体内显像清晰,直肠下段NET患者显像可见直肠下段肠壁病灶SUVmax为13.3,肿瘤/肝脏比值为3.3,肝脏、淋巴结、肋骨转移灶均显示较高的SUVmax和肿瘤/肝脏比值;胰腺NET患者显像可见胰头钩突处局灶性显像剂摄取异常增高,SUVmax为5.6,2 h后显像的SUVmax为6.3,肿瘤/肝脏比值为2.3。结论利用GE-FASTLab2合成模块能高活度地制备^(18)F-AlF-NOTATATE,制备方法简单、稳定,产品放化纯高。^(18)F-AlF-NOTATATE PET/CT显像在NET患者体内显示出较好的显像效果,能够为诊治和预后评估提供有价值的信息。Objective To establish an automated labeling method of ^(18)F-AlF-1,4,7-triazocyclohexane-1,4,7-triacetic acid-D-Phe1-Tyr3-Thr8-octreotide(NOTATATE)and perform neuroendocrine tumor(NET)imaging.Methods Based on the GE-FASTLab2 synthesis module,^(18)F-AlF-NOTATATE was automatically prepared by one-step chelation labeling with aluminum fluoride,and its labeling conditions were optimized.The product quality was analyzed.One patient(male,47 years old)with lower rectal segment NET and one patient(female,52 years old)with pancreatic NET underwent ^(18)F-AlF-NOTATATE PET/CT imaging.Results ^(18)F-AlF-NOTATATE was successfully prepared with a total synthesis time of 35 min.The optimized radiochemical yield was(23.8±3.1)%(without decay correction,n=3),the radioactivity was(4.63±0.68)GBq,and the radiochemical purity was>95%.The stability was good,and the product quality met the requirements.^(18)F-AlF-NOTATATE showed clear imaging in the patient with rectal segment NET,with SUVmax of 13.3 and tumor/liver ratio of 3.3.Metastatic lesions in the liver,lymph nodes,and ribs showed high SUVmax and tumor/liver ratios.The imaging of the pancreatic NET patient showed an abnormal increase in local radioactive uptake at the uncinate process of the pancreatic head,with SUVmax of 5.6 and SUVmax of 6.3 and the tumor/liver ratio of 2.3 after 2-hours imaging.Conclusions Using the GE-FASTLab2 synthesis module,^(18)F-AlF-NOTATATE can be prepared with high activity.The preparation is simple,the method is stable,and the product has high radiochemical purity.^(18)F-AlF-NOTATATE exhibits good imaging performance in NET patients,providing valuable information for diagnosis,treatment,and prognosis evaluation.

关 键 词：神经内分泌瘤 受体 生长抑素 同位素标记 氟放射性同位素 正电子发射断层显像术 体层摄影术 X线计算机 

分 类 号：R739.4[医药卫生—肿瘤] R730.44[医药卫生—临床医学]