婴儿癫痫性痉挛综合征治疗现状  

Current status of treatment for infantile epileptic spasm syndrome

作　　者：赵考明 易招师[1] 钟建民[1] ZHAO Kaoming;YI Zhaoshi;ZHONG Jianmin(Department of Neurology,Jiangxi Children's Hospital,NanChang 330006,China)

机构地区：[1]江西省儿童医院神经内科,南昌330006

出　　处：《癫痫杂志》2024年第4期332-339,共8页Journal of Epilepsy

基　　金：江西省科技厅重点研发计划一般项目(20203BBGL73132)。

摘　　要：婴儿癫痫性痉挛综合征(Infantile epileptic spasm syndrome,IESS)是一种年龄依赖性癫痫性脑病,多于3~12个月内起病,常用抗癫痫发作药物(Anti-seizure medications,ASMs)疗效不佳,远期控制率低,复发率高,常遗留有发育落后/智力障碍、孤独症谱系障碍等后遗症。目前IESS的一线推荐治疗为促肾上腺皮质激素(Adrenocorticotropic hormone,ACTH)、肾上腺皮质激素和氨己烯酸,无效者可试用其他ASMs、生酮饮食和手术治疗等。本文将对IESS治疗现状及相关临床应用综述如下。Infantile epileptic spasm syndrome(IESS)is an age-dependent epileptic encephalopathy that onset within 3~12 months.Commonly used Anti-seizure medications(ASMs)have poor efficacy,low long-term control rate and high recurrence rate,and often leave behind sequelae such as developmental delay/intellectual disability,and autism spectrum disorders.At present,the first-line recommended treatments for IESS are Adrenocorticotropic hormone(ACTH),adrenocortical hormone and vigabatrin.If ineffective,other ASMs,ketogenic diets,and surgical treatments can be tried.This article will provide a review of the current status and related clinical applications of IESS treatment.

关 键 词：婴儿癫痫性痉挛综合征 治疗 预后 

分 类 号：R742.1[医药卫生—神经病学与精神病学]