经皮三叉神经刺激治疗癫痫的中枢调节机制及参数研究进展  

Research progress on central regulatory mechanism and parameters of percutaneous trigeminal nerve stimulation in the treatment of epilepsy

作　　者：申佳 孙凡雅 李蓉[2] 朱博 丁乐 郭坤 雍芳[2] 顾乃兵[2] 狄政莉[2] SHEN Jia;SUN Fanya;LI Rong;ZHU Bo;DING Le;GUO Kun;YONG Fang;GU Naibing;DI Zhengli(Medical School of Yan’an University,Yan’an 716000,China;Department of Neurology,Xi'an Central Hospital,Xi’an 710000,China)

机构地区：[1]延安大学医学院,延安716000 [2]西安市中心医院神经内科,西安710000

出　　处：《癫痫杂志》2024年第4期340-344,共5页Journal of Epilepsy

基　　金：陕西省重点研发计划(2022SF-418);西安市中心医院科研项目(2023ZD01)。

摘　　要：经皮三叉神经电刺激(external Trigeminal nerve stimulation,eTNS)是一种基于三叉神经解剖学特点发展而来的新兴的无创性物理电刺激疗法,通过调节癫痫相关的脑干核团及部分前脑结构、调节神经炎症、改善突触可塑性和促进神经发生等控制癫痫发作,临床应用前景广阔。目前已经被欧盟批准用于9岁以上耐药性癫痫患者的辅助治疗。因此,本文主要围绕eTNS改善癫痫的中枢神经系统调节机制、eTNS刺激模式及参数进行综述。External trigeminal nerve stimulation(eTNS)is a new non-invasive physical and electrical stimulation therapy based on the anatomical characteristics of the trigeminal nerve.It can control seizures by regulating epilepsiarelated brainstem nuclei and part of forebrain structures,regulating neuroinflammation,improving synaptic plasticity and promoting neurogenesis,which has broad clinical application prospects.It has been approved by the European Union as an adjuvant treatment for drug-resistant epilepsy patients over the age of 9 years old.Therefore,this article mainly reviews the central nervous system regulatory mechanism of eTNS in improving epilepsy,eTNS stimulation mode and parameters.

关 键 词：三叉神经刺激 癫痫 神经递质 刺激参数 

分 类 号：R742.1[医药卫生—神经病学与精神病学]