7 T MR血管成像评估豆纹动脉形态学特征  

Evaluation of lenticular artery morphological features based on 7 T MR angiography

作　　者：李润泽 吕晋浩 段祺 王婉冰 王心宇 娄昕[2] LI Runze;LYU Jinhao;DUAN Qi;WANG Wanbing;WANG Xinyu;LOU Xin(Medical School of Chinese PLA,Beijing 100853,China;Department of Radiology,First Medical Center of PLA General Hospital)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一医学中心放射诊断科

出　　处：《国际医学放射学杂志》2024年第4期412-417,424,共7页International Journal of Medical Radiology

基　　金：国家自然科学基金项目(81825012,82327803,82151309,82271952)。

摘　　要：目的基于超高场强7 T时间飞跃MR血管成像(7 T TOF MRA),探讨症状性和无症状性大脑中动脉(MCA)粥样硬化性狭窄病人中豆纹动脉(LSA)形态学指标的差异。方法前瞻性连续纳入诊断为单侧MCA M1段狭窄的病人39例,平均年龄(54.36±2.05)岁,男31例(79.49%)。根据病人有无症状将病人分为有症状组19例(48.72%)和无症状组20例(51.28%)。根据MCA M1段狭窄程度,2组病人细分为非重度狭窄和重度狭窄2个亚组,其中症状组中非重度狭窄11例,重度狭窄8例;无症状组中非重度狭窄10例,重度狭窄10例。由1名医师在7 T TOF MRA影像上分别评估病人双侧大脑半球的LSA形态学指标,包括LSA的主干数量、分支数量、长度和曲度。采用独立样本t检验、Fisher确切概率检验对病人临床资料进行分析;采用双因素方差分析2组及亚组间的LSA形态学差异,使用配对t检验分析亚组病人患侧和健侧LSA的形态学差异。结果有症状组的LSA分支数量和曲度均减小(均P<0.05)。无症状组中重度狭窄病人患侧的LSA分支数量多于健侧(均P<0.05);有症状组病人患侧的LSA分支数量少于健侧、LSA长度短于健侧,其中重度狭窄病人患侧LSA曲度小于健侧(均P<0.05)。有症状组和无症状组病人的双侧大脑半球LSA的其他形态学指标比较,差异均无统计学意义(均P>0.05)。结论症状性MCA M1段狭窄会导致患侧LSA分支数量减少及长度缩短,而重度狭窄未必会导致LSA分支数量的减少。Objective To explore the differences in the morphological characteristics of lenticulostriate arteries(LSAs)in patients with symptomatic and asymptomatic middle cerebral artery(MCA)atherosclerotic stenosis using ultra-high-field 7 T time-of-flight MR angiography(7 T TOF MRA).Methods This prospective study continuously included 39 patients diagnosed with unilateral MCA M1 segment stenosis,with an average age of 54.36±2.05 years,31 cases were male(79.49%).Patients were divided into symptomatic(19 cases,48.72%)and asymptomatic groups(20 cases,51.28%)based on their symptoms.According to the degree of MCA M1 stenosis,patients were further subdivided into non-severe and severe stenosis subgroups.The symptomatic group had 11 cases of non-severe stenosis and 8 cases of severe stenosis,while the asymptomatic group had 10 cases of non-severe stenosis and 10 cases of severe stenosis.One physician assessed the LSA morphological indicators,including the number of trunks,number of branches,length,and tortuosity of the LSAs,on both hemispheres of the brain using 7 T TOF MRA images.Clinical data were analyzed using an independent samples t-test and Fisher’s exact test.Two-way ANOVA was used to analyze the differences in LSA morphology between the groups and subgroups,and a paired t-test was used to compare the morphological differences between the affected and unaffected sides within the subgroups.Result The symptomatic group showed a reduction in both the number of LSA branches and tortuosity(both P<0.05).In the asymptomatic group with severe stenosis,the number of LSA branches on the affected side was greater than on the unaffected side(P<0.05).In the symptomatic group,the number of LSA branches and the length of the LSA on the affected side were smaller than those on the unaffected side.Among patients with severe stenosis in the symptomatic group,the tortuosity of the LSA on the affected side was smaller than that on the unaffected side(both P<0.05).There were no statistically significant differences in other morphological

关 键 词：超高场强 磁共振成像 豆纹动脉血管病 颅内动脉粥样硬化 脑血管病 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]