Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice  

作　　者：Chunyan Zhu Xuemin Yao Dandan Liu Guoxin Zhang Yongping Zhu Hongyu Chi Shuangpan Zhang Jun Yang Ying Liu Jigang Wang Na Lin 

机构地区：[1]Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第2期287-290,共4页药物分析学报（英文版）

基　　金：supported by the grants from the Natural Science Foundation of Beijing Municipality(Grant No.:7212185);the Scientific and Technological Innovation project of China Academy of Chinese Medical Sciences(Grant No.:CI2021A03808);the National Natural Science Foundation of China(Grant Nos.:82330124,81974526,and 82274176);the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine,China(Program No.:ZYYCXTD-C-202002);the Special Project for Training Outstanding Young Scientific and Technological Talents(innovative type)of Necessary Scientific Research Business Expenses of China Academy of Chinese Medical Sciences(Project Nos.:ZZ13-YQ-051,and ZZ15-YQ-063);the Fundamental Research Funds for the Central public welfare research institutes(Grant No.:ZXKT21010).

摘　　要：Nowadays,roughly 603.7 million people are bothered by obesity[1].More seriously,obesity brings inflammation to the peripheral and central nervous system,which compromises the comorbidity of obesity,major depression[2],and cognitive deficits[3].Drug competent in the comorbidity is still lacking.In 2015,Liu et al.[4]reported celastrol(CEL)as a powerful anti-obesity agent.In our previous study.

关 键 词：inflammation OBESITY OBESE 

分 类 号：R96[医药卫生—药理学]