基于免疫因子探索焦虑障碍的态靶辨治策略  

Study on the "syndrome differentiation and target therapy" strategy for anxiety disorders based on immune factors

作　　者：李昀熹 林婉儿 杨玲玲[1] 李艳[1] LI Yunxi;LIN Waner;YANG Lingling;LI Yan(Department of Psychology and Sleep,Guangdong Hospital of Traditional Chinese Medicine/Tong Xiaolin Academic Experience Inheritance Studio,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510030,China;Department of Ophthalmology,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510030,China)

机构地区：[1]广东省中医院心理睡眠科/广东省中医院仝小林学术经验传承工作室,广州510030 [2]广东省中医院眼科,广州510030

出　　处：《吉林中医药》2024年第7期764-767,共4页Jilin Journal of Chinese Medicine

基　　金：仝小林学术经验传承工作室(中医二院[2022]106号);广东省中医药局科研项目(20223036);广州市科技计划市校(院)联合资助项目(2023A03J0228)。

摘　　要：仝小林院士创造性提出“态靶因果”学说,有机结合传统中医学与现代医学,全面审视疾病发展各阶段的特点和规律,利用前沿科学理论与研究方法技术搭建现代疾病与中医证候的桥梁,促进中西医深入融合。依据态靶辨治理论体系,将焦虑障碍的总态概括为“虚”,在不同严重程度分别呈现“郁”“虚”“热”“损”态。通过临床诊疗经验及现代中药药理学进展,总结焦虑障碍的调态靶方,阐明其生物学标靶可能为调节免疫因子,推进焦虑障碍的“辨证微观化”与“精准用药”。Academician Tong Xiaolin creatively put forward the doctrine of "syndrome differentiation and target therapy",which organically integrates traditional Chinese medicine with modern medicine,comprehensively examines the characteristics and laws at each stage of disease development,and forms a bridge between modern diseases and TCM syndromes by applying cutting-edge scientific theories and research methods to promote the indepth integration of Chinese and western medicine.According to the theoretical system of "syndrome differentiation and target therapy",this paper concludes that the general state of anxiety disorders can be characterized by "deficiency",and is manifested as "depression","deficiency","heat",and "damage" states at different severity levels.Learning from the clinical diagnosis and treatment experience and leveraging the progress of modern Chinese medicine pharmacology,this study works out the target formula for anxiety disorders,clarifies that their biological targets may involve regulating immune factors,and promotes the "microscopic syndrome differentiation" and "precise medication" in the treatment of anxiety disorders.

关 键 词：态靶辨治 焦虑障碍 证候 靶方 靶药 免疫因子 

分 类 号：R749.7[医药卫生—神经病学与精神病学]