恶性周围神经鞘膜瘤胸膜转移1例  

A case of pleural metastasis of malignant peripheral nerve sheath tumor

作　　者：黄敏轩 唐攀 岑天天 贾潇天 孙超[1] 金洁 赖宁燕 陈众博[1] 丁群力[1] 陶凤云 马红映[1] Huang Minxuan;Tang Pan;Cen Tiantian;Jia Xiaotian;Sun Chao;Jin Jie;Lai Ningyan;Chen Zhongbo;Ding Qunli;Tao Fengyun;Ma Hongying(Department of Respiratory and Critical Care Medicine,the First Hospital of Ningbo University,Ningbo Key Laboratory of Respiratory Disease,Ningbo 315000,China;Department of Hand Surgery,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China;Ningbo Clinical Pathology Diagnostic Center,Ningbo 315000,China)

机构地区：[1]宁波大学附属第一医院呼吸与危重症医学科,宁波市呼吸疾病研究重点实验室,宁波315000 [2]复旦大学附属华山医院手外科,上海200040 [3]宁波市临床病理诊断中心,宁波315000

出　　处：《中华结核和呼吸杂志》2024年第7期658-662,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：恶性周围神经鞘膜瘤(malignant peripheral nerve sheath tumor, MPNST)常转移至肺, 胸膜转移罕见。本文报道1例MPNST胸膜转移患者。患者青年男性, 因"气促伴干咳1周"就诊。既往恶性周围神经鞘膜瘤病史。内科胸腔镜胸膜活检病理提示短梭形细胞增生, 胸膜病理切片免疫组织化学染色S-100(+)、SOX-10(+)、Ki-67(+)阳性指数20%、H3K27Me3(-), 诊断为MPNST胸膜转移。Malignant peripheral nerve sheath tumor(MPNST)frequently metastasizes to the lungs,although pleural metastasis is rare.This article reported a case of pleural metastasis of MPNST.The patient was a young man who presented with 1 week of shortness of breath with dry cough.He had a history of malignant peripheral nerve sheath tumor.The patient was diagnosed with MPNST pleural metastasis after a thoracoscopic pleural biopsy,which revealed short spindle cell hyperplasia,immunohistochemical staining for S-100(+),SOX-10(+),Ki-67(+)with a positive index of 20%,and H3K27Me3(-)in the pleural pathology.

关 键 词：胸膜转移 恶性周围神经鞘膜瘤 

分 类 号：R739.4[医药卫生—肿瘤]