抑郁伴失眠患者血清炎症因子表达及临床意义  

Expression and clinical significance of serum inflammatory factors in patients with depression and insomnia

作　　者：陈晓勇[1] 赵丽花 林紫薇[1] 赵家龙 颜闪闪 崔曼曼 高理升 CHEN Xiaoyong;ZHAO Lihua;LIN Ziwei(General Medicine Department,the People's Hospital Bozhou,Bozhou 236800,China)

机构地区：[1]亳州市人民医院全科医学科,亳州236800 [2]中科院合肥物理研究所

出　　处：《国际精神病学杂志》2024年第3期769-772,共4页Journal Of International Psychiatry

基　　金：国家重点研发计划课题(编号:2020YFC2005603)。

摘　　要：目的观察抑郁伴失眠患者血清炎症因子表达水平并探讨其临床意义。方法选择2021年3月~2023年3月本院收治的抑郁伴失眠患者112例,将其作为观察组,另选50名体检健康者作为对照组。记录各组汉密尔顿抑郁量表17项版(17-Item Hamilton Depression Scale,HAMD-17)评分、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分;检测各组血清炎症因子[白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1β,IL-1β)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平;以Pearson相关系数检验相关性。结果观察组HAMD-17评分及PSQI评分分别为(22.16±5.82)分、(15.09±2.35)分,高于对照组的(6.09±0.74)分、(7.13±2.78)分,P<0.05;观察组血清IL-6、IL-1β、TNF-α水平分别为(28.95±6.32)pg/mL、(35.82±8.37)pg/mL、(45.69±5.81)pg/mL,高于对照组的(24.17±3.55)pg/mL、(30.29±3.75)pg/mL、(42.37±3.12)pg/mL,P<0.05;其中轻度组、中度组、重度组HAMD-17评分、PSQI评分及血清IL-6、IL-1β、TNF-α水平比较,差异有统计学意义(P<0.05);抑郁伴失眠患者HAMD-17评分与PSQI评分及血清IL-6、IL-1β、TNF-α水平存在正相关关系(P<0.05)。结论与健康对照组相比,抑郁伴失眠患者血清IL-6、IL-1β、TNF-α水平均较高,并且血清炎症因子水平与其抑郁症严重程度存在一定的相关性。Objective To observe the expression level of serum inflammatory factors in patients with depression and insomnia and explore its clinical significance.Methods A total of 112 patients with depression and insomnia admitted to our hospital from March 2021 to March 2023 were selected as the observation group,and 50 healthy subjects were selected as the control group.17-Item Hamilton Depression Scale(HAMD-17)score and Pittsburgh Sleep Quality Index(PSQI)score were recorded.The levels of serum inflammatory factors such as interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were detected in all groups.Pearson correlation coefficient was used to test the correlation.Results HAMD-17 scores and PSQI scores in the observation group were(22.16±5.82)scores and(15.09±2.35)scores,respectively,higher than those in the control group(6.09±0.74)scores and(7.13±2.78)scores,P<0.05.Serum levels of IL-6,IL-1βand TNF-αin the observation group were(28.95±6.32)pg/mL,(35.82±8.37)pg/mL and(45.69±5.81)pg/mL,respectively.It was higher than that of control group(24.17±3.55)pg/mL,(30.29±3.75)pg/mL,(42.37±3.12)pg/mL,P<0.05.There were significant differences in HAMD-17 scores,PSQI scores and serum levels of IL-6,IL-1βand TNF-αin mild,moderate and severe groups(P<0.05).HAMD-17 score was positively correlated with PSQI score and serum levels of IL-6,IL-1βand TNF-αin patients with depression and insomnia(P<0.05).Conclusion Compared with the healthy control group,the se-rum levels of IL-6,IL-1βand TNF-αwere higher in patients with depression and insomnia,and the serum levels of inflammatory factors were correlated with the severity of depression.

关 键 词：抑郁症 失眠 炎症因子 相关性分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]