母亲童年创伤对青少年抑郁患者创伤、焦虑及杏仁核脑网络影响  

The impact of maternal childhood trauma affecting trauma,anxiety and amygdala brain network in adolescent depressed patient

作　　者：冯文泰 阳洁 周敏思 高铭 宋仕琪 孙雨蒙 林玲 薛振朋 徐健昌 刘剑波 卢建平 FENG Wentai;YANG Jie;ZHOU Minsi(Shenzhen mental health center/shenzhen Kangning Hospital,Anhui Medical University,Shenzhen 518000,China)

机构地区：[1]安徽医科大学深圳精神卫生临床学院,深圳518000 [2]深圳市精神卫生中心/深圳市康宁医院 [3]中南大学湘雅二医院

出　　处：《国际精神病学杂志》2024年第3期783-787,791,共6页Journal Of International Psychiatry

基　　金：深圳市科技计划项目(编号:JCYJ20190809155019338);广东省基础与应用基础研究基金项目(编号:2019A1515110047)。

摘　　要：目的了解母亲童年创伤对青少年抑郁症患者童年创伤和焦虑情绪及后代脑机制的影响。方法采用量表或问卷对住院抑郁发作青少年及其母亲和健康组青少年及其母亲进行调查。在青少年抑郁发作患者中,选择杏仁核作为感兴趣区域,比较有无童年创伤母亲后代的全脑静息状态功能连接。结果(1)抑郁发作组母亲躯体忽视得分、情感虐待得分、情感忽视得分,焦虑抑郁情绪得分显著高于健康组母亲,差异具有统计学意义(P<0.05);(2)在抑郁发作青少年中,母亲遭受童年创伤组较母亲未遭受童年创伤组,后代焦虑情绪得分和童年创伤因子分及其总分均无统计学差异(P>0.05);(3)在抑郁发作青少年中,有母亲童年创伤的后代与没有母亲童年创伤的后代相比,以杏仁核作为感兴趣区与海马旁回、舌回、枕下回、额上回等脑区的功能连接值降低。结论母亲童年创伤及焦虑抑郁情绪可能增加后代抑郁症发病风险,且母亲童年创伤影响后代以杏仁核为种子点的脑功能网络,但母亲童年创伤不影响青少年抑郁症患者焦虑症状及童年创伤严重程度。Objective Understanding the impact of maternal childhood trauma on childhood trauma and anxiety in adolescents with depression and on the brain mechanisms of their offspring.Methods Scales or questionnaires were used to investigate hospitalized adolescents with depressive episodes and their mothers and healthy adolescents and their mothers.In patients with adolescent depressive episodes,the amygdala was selected as the region of interest to compare whole-brain resting-state functional connectivity in offspring of mothers with and without childhood trauma.Results(1)The physical neglect scores,emotional abuse scores,emotional neglect scores,anxiety and depression scores of mothers in the depressive episode group were significantly higher than those of mothers in the healthy group,the difference was statistically significant(P<0.05).(2)Among the adolescents with depressive episodes,there were no significant differences in anxiety scores and childhood trauma factor scores and its total scores between the group whose mothers suffered childhood trauma and the group whose mothers did not suffer childhood trauma(P>0.05).(3)In adolescents with depressive episodes,offspring with maternal childhood trauma had reduced values of functional connectivity between the amygdala as a region of interest and brain regions such as parahippocampal gyrus,lingual gyrus,suboccipital gyrus,suprafrontal gyrus etc,compared to offspring without maternal childhood trauma.Conclusion Maternal childhood trauma and anxiety and depression may increase the risk of depression in offspring,and maternal childhood trauma affects the brain functional network of offspring with the amygdala as the seed point,but maternal childhood trauma does not affect anxiety symptoms and severity of childhood trauma in adolescents with depression.

关 键 词：童年创伤 抑郁症 母亲童年创伤 代际传递 脑机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]