CBT联合氟西汀对食管癌根治术后患者情绪、免疫功能及血清细胞因子的影响  

Effects of CBT combined with fluoxetine on psychological emotion,immune function and serum cytokines in esophageal cancer patients after thoracoscopic radical resection

作　　者：陈鑫[1] 孙志红[1] 葛鹏[1] CHEN Xin;SUN Zhihong;GE Peng(The Second Affiliated Hospital of Xi'an Medical College,Xi'an 710038,China)

机构地区：[1]西安医学院第二附属医院,西安710038

出　　处：《国际精神病学杂志》2024年第3期935-937,976,共4页Journal Of International Psychiatry

基　　金：西安市创新能力强基计划(编号:21YXYJ0130)。

摘　　要：目的 探索认知行为疗法(CBT)联合氟西汀对胸腔镜食管癌根治术后患者情绪、免疫能力及血清细胞因子的影响。方法 回顾性选取我院2020年6月~2022年9月期间102例胸腔镜食管癌根治术后患者作为研究对象,随机数字表法分为药物组和综合组。药物组51例予氟西汀治疗,综合组51例增加CBT治疗,对比两组患者情绪状态、免疫功能及血清细胞因子。结果 两组治疗8周后贝克焦虑量表(BAI)、贝克抑郁量表(BDI)评分较治疗前降低,综合组低于药物组(P<0.05)。两组治疗8周后CD4^(+)水平较治疗前升高,综合组高于药物组;CD8^(+)水平较治疗前降低,综合组低于药物组(P<0.05)。两组治疗8周后白细胞介素1β(IL-1β)、肿瘤坏死因子(TNF-α)水平较治疗前降低,综合组低于药物组;白细胞介素10(IL-10)水平较治疗前升高,综合组高于药物组(P<0.05)。结论 CBT联合氟西汀可调节胸腔镜食管癌根治术后患者血清细胞因子水平,改善其情绪,提高免疫能力。Objective To explore the effects of cognitive behavioral therapy(CBT)combined with fluoxetine on emotion,immune capacity and serum cytokines in esophageal cancer patients after thoracoscopic radical resection.Methods A total of 102 patients with thoracoscopic esophageal cancer after radical surgery in our hospital from June 2020 to September 2022 were retrospectively selected as the study objects,and were divided into drug group and comprehensive group by random number table method.Fifty-one patients in the drug group were treated with fluoxetine,while 51 patients in the comprehensive group were treated with CBT.Psychological discomfort,immune capacity and serum cytokines were compared between the two groups.Results After 8 weeks of treatment,the scores of Baker Anxiety Scale(BAI)and Baker Depression Scale(BDI)in both groups were lower than before treatment,and the comprehensive group was lower than that in drug group(P<0.05).After 8 weeks of treatment,CD4+level in both groups was higher than that before treatment,and that in the comprehensive group was higher than that in the drug group.The level of CD8+was lower than before treatment,and the comprehensive group was lower than drug group(P<0.05).After 8 weeks of treatment,the levels of interleukin1β(IL-1β)and tumor necrosis factor(TNF-α)in both groups were lower than before treatment,and the comprehensive group was lower than the drug group.The level of interleukin-10(IL-10)was higher than that before treatment,and the comprehensive group was higher than that of drug group(P<0.05).Conclusion CBT combined with fluoxetine can regulate serum cytokine levels in esophageal cancer patients after thoracoscopic radical resection,improve their emotion,and enhance their immune capacity.

关 键 词：认知行为疗法 氟西汀 食管癌根治术 情绪 

分 类 号：R749[医药卫生—神经病学与精神病学]